Human Gene CCDC157 (uc011aku.2)
  Description: Homo sapiens coiled-coil domain containing 157 (CCDC157), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr22:30,752,627-30,772,818 Size: 20,192 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr22:30,761,990-30,772,734 Size: 10,745 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:30,752,627-30,772,818)mRNA (may differ from genome)Protein (752 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CC157_HUMAN
DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 157;
SEQUENCE CAUTION: Sequence=AAH92419.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB33326.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5'- and 3'-ends and extensively differs from that shown due to multiple introns;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.47 RPKM in Testis
Total median expression: 87.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -325.31660-0.493 Picture PostScript Text
3' UTR -43.4084-0.517 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q569K6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Descriptions from all associated GenBank mRNAs
  BC018040 - Homo sapiens cDNA clone IMAGE:4798973.
BC092419 - Homo sapiens coiled-coil domain containing 157, mRNA (cDNA clone MGC:102960 IMAGE:30383661), complete cds.
CR936833 - Homo sapiens mRNA; cDNA DKFZp434J071 (from clone DKFZp434J071).
BC119799 - Homo sapiens coiled-coil domain containing 157, mRNA (cDNA clone IMAGE:40108737), partial cds.
BC127255 - Homo sapiens coiled-coil domain containing 157, mRNA (cDNA clone IMAGE:40108738), partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: CC157_HUMAN, KIAA1656, NM_001017437, NP_001017437, Q0VD76, Q569K6, Q9BYA4
UCSC ID: uc011aku.2
RefSeq Accession: NM_001017437
Protein: Q569K6 (aka CC157_HUMAN)
CCDS: CCDS33632.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001017437.2
exon count: 12CDS single in 3' UTR: no RNA size: 3023
ORF size: 2259CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 4481.00frame shift in genome: no % Coverage: 99.34
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.