Human Gene RABL2B (uc011asg.1)
  Description: Homo sapiens RAB, member of RAS oncogene family-like 2B (RABL2B), transcript variant 3, mRNA.
RefSeq Summary (NM_001130919): The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is located within a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Transcript (Including UTRs)
   Position: hg19 chr22:51,205,920-51,222,087 Size: 16,168 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr22:51,207,204-51,220,722 Size: 13,519 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:51,205,920-51,222,087)mRNA (may differ from genome)Protein (229 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMGIOMIMPubMedTreefam
UniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.29 RPKM in Brain - Cerebellum
Total median expression: 306.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -93.20212-0.440 Picture PostScript Text
3' UTR -404.511284-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF04670 - Gtr1/RagA G protein conserved region
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9UNT1-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Descriptions from all associated GenBank mRNAs
  BC040495 - Homo sapiens RAB, member of RAS oncogene family-like 2B, mRNA (cDNA clone IMAGE:5296675), with apparent retained intron.
BC014879 - Homo sapiens RAB, member of RAS oncogene family-like 2B, mRNA (cDNA clone MGC:10160 IMAGE:3906749), complete cds.
BC064551 - Homo sapiens RAB, member of RAS oncogene family-like 2B, mRNA (cDNA clone IMAGE:5555950), partial cds.
BC075856 - Homo sapiens cDNA clone IMAGE:5172972, containing frame-shift errors.
BC024281 - Homo sapiens RAB, member of RAS oncogene family-like 2B, mRNA (cDNA clone MGC:39195 IMAGE:4580599), complete cds.
AK094341 - Homo sapiens cDNA FLJ37022 fis, clone BRACE2010813, moderately similar to Homo sapiens RAB-like protein 2B (RABL2B) mRNA.
AF095352 - Homo sapiens RAB-like protein 2B (RABL2B) mRNA, complete cds.
JD460433 - Sequence 441457 from Patent EP1572962.
JD403558 - Sequence 384582 from Patent EP1572962.
JD046727 - Sequence 27751 from Patent EP1572962.
JD504365 - Sequence 485389 from Patent EP1572962.
JD378855 - Sequence 359879 from Patent EP1572962.
JD317824 - Sequence 298848 from Patent EP1572962.
JD038669 - Sequence 19693 from Patent EP1572962.
JD261458 - Sequence 242482 from Patent EP1572962.
JD114397 - Sequence 95421 from Patent EP1572962.
JD074124 - Sequence 55148 from Patent EP1572962.
JD488169 - Sequence 469193 from Patent EP1572962.
JD128221 - Sequence 109245 from Patent EP1572962.
JD165738 - Sequence 146762 from Patent EP1572962.
JD135566 - Sequence 116590 from Patent EP1572962.
JD519890 - Sequence 500914 from Patent EP1572962.
JD479040 - Sequence 460064 from Patent EP1572962.
JD407766 - Sequence 388790 from Patent EP1572962.
JD258873 - Sequence 239897 from Patent EP1572962.
JD228613 - Sequence 209637 from Patent EP1572962.
JD227558 - Sequence 208582 from Patent EP1572962.
JD527703 - Sequence 508727 from Patent EP1572962.
JD198438 - Sequence 179462 from Patent EP1572962.
JD488413 - Sequence 469437 from Patent EP1572962.
JD527704 - Sequence 508728 from Patent EP1572962.
JD546050 - Sequence 527074 from Patent EP1572962.
JD198439 - Sequence 179463 from Patent EP1572962.
JD272061 - Sequence 253085 from Patent EP1572962.
JD140627 - Sequence 121651 from Patent EP1572962.
JD294984 - Sequence 276008 from Patent EP1572962.
JD527705 - Sequence 508729 from Patent EP1572962.
JD247459 - Sequence 228483 from Patent EP1572962.
JD325923 - Sequence 306947 from Patent EP1572962.
JD367232 - Sequence 348256 from Patent EP1572962.
JD198440 - Sequence 179464 from Patent EP1572962.
JD559320 - Sequence 540344 from Patent EP1572962.
JD140628 - Sequence 121652 from Patent EP1572962.
JD523606 - Sequence 504630 from Patent EP1572962.
JD140629 - Sequence 121653 from Patent EP1572962.
JD523607 - Sequence 504631 from Patent EP1572962.
JD527702 - Sequence 508726 from Patent EP1572962.
JD527699 - Sequence 508723 from Patent EP1572962.
JD266127 - Sequence 247151 from Patent EP1572962.
JD549899 - Sequence 530923 from Patent EP1572962.
JD386105 - Sequence 367129 from Patent EP1572962.
JD301269 - Sequence 282293 from Patent EP1572962.
JD397641 - Sequence 378665 from Patent EP1572962.
JD206769 - Sequence 187793 from Patent EP1572962.
JD451621 - Sequence 432645 from Patent EP1572962.
JD417899 - Sequence 398923 from Patent EP1572962.
JD253609 - Sequence 234633 from Patent EP1572962.
JD418718 - Sequence 399742 from Patent EP1572962.
JD554006 - Sequence 535030 from Patent EP1572962.
AK313442 - Homo sapiens cDNA, FLJ93981.
CU677101 - Synthetic construct Homo sapiens gateway clone IMAGE:100016829 5' read RABL2B mRNA.
KJ893240 - Synthetic construct Homo sapiens clone ccsbBroadEn_02634 RABL2B gene, encodes complete protein.
BT020037 - Homo sapiens RAB, member of RAS oncogene family-like 2B mRNA, complete cds.
DQ892360 - Synthetic construct clone IMAGE:100004990; FLH185541.01X; RZPDo839C04148D RAB, member of RAS oncogene family-like 2B (RABL2B) gene, encodes complete protein.
DQ895567 - Synthetic construct Homo sapiens clone IMAGE:100010027; FLH185537.01L; RZPDo839C04147D RAB, member of RAS oncogene family-like 2B (RABL2B) gene, encodes complete protein.
AK308268 - Homo sapiens cDNA, FLJ98216.
BC020495 - Homo sapiens RAB, member of RAS oncogene family-like 2B, mRNA (cDNA clone IMAGE:3902486), with apparent retained intron.
KJ902210 - Synthetic construct Homo sapiens clone ccsbBroadEn_11604 RABL2B gene, encodes complete protein.
DQ581316 - Homo sapiens piRNA piR-49428, complete sequence.
JD132799 - Sequence 113823 from Patent EP1572962.
JD049902 - Sequence 30926 from Patent EP1572962.
JD137727 - Sequence 118751 from Patent EP1572962.
JD211753 - Sequence 192777 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001130919, NP_001124393, Q9UNT1-2
UCSC ID: uc011asg.1
RefSeq Accession: NM_001130919
Protein: Q9UNT1-2, splice isoform of Q9UNT1 CCDS: CCDS14102.1, CCDS33683.1, CCDS46738.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001130919.1
exon count: 9CDS single in 3' UTR: no RNA size: 2186
ORF size: 690CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1580.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.