Description: Homo sapiens xylulokinase homolog (H. influenzae) (XYLB), mRNA. RefSeq Summary (NM_005108): The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]. Transcript (Including UTRs) Position: hg19 chr3:38,388,251-38,456,467 Size: 68,217 Total Exon Count: 17 Strand: + Coding Region Position: hg19 chr3:38,407,132-38,454,504 Size: 47,373 Coding Exon Count: 14
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): XYLB CDC HuGE Published Literature: XYLB Positive Disease Associations: Electrocardiography Related Studies:
Electrocardiography J Gustav Smith et al. Heart rhythm 2009, Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae., Heart rhythm : the official journal of the Heart Rhythm Society.
[PubMed 19389651]
The PR interval and its subcomponents showed substantial heritability in a South Pacific islander population and were associated with common genetic variation in SCN5A.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75191
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0005997 xylulose metabolic process GO:0005998 xylulose catabolic process GO:0006091 generation of precursor metabolites and energy GO:0016310 phosphorylation GO:0019640 glucuronate catabolic process to xylulose 5-phosphate GO:0042732 D-xylose metabolic process GO:0046835 carbohydrate phosphorylation