ID:MYRIP_HUMAN DESCRIPTION: RecName: Full=Rab effector MyRIP; AltName: Full=Exophilin-8; AltName: Full=Myosin-VIIa- and Rab-interacting protein; AltName: Full=Synaptotagmin-like protein lacking C2 domains C; Short=SlaC2-c; Short=Slp homolog lacking C2 domains c; FUNCTION: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). SUBUNIT: Binds MYO5A, MYO7A and F-actin (By similarity). Binds RAB27A that has been activated by GTP-binding via its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cytoplasmic vesicle, secretory vesicle (By similarity). Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments (By similarity). TISSUE SPECIFICITY: Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis. SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 1 RabBD (Rab-binding) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NFW9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0030050 vesicle transport along actin filament GO:0032024 positive regulation of insulin secretion