Description: Homo sapiens dynein, axonemal, heavy chain 1 (DNAH1), mRNA. RefSeq Summary (NM_015512): This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017]. Transcript (Including UTRs) Position: hg19 chr3:52,350,335-52,434,513 Size: 84,179 Total Exon Count: 78 Strand: + Coding Region Position: hg19 chr3:52,356,459-52,434,462 Size: 78,004 Coding Exon Count: 77
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF03028 - Dynein heavy chain and region D6 of dynein motor PF07728 - AAA domain (dynein-related subfamily) PF08393 - Dynein heavy chain, N-terminal region 2 PF12774 - Hydrolytic ATP binding site of dynein motor region D1 PF12775 - P-loop containing dynein motor region D3 PF12777 - Microtubule-binding stalk of dynein motor PF12780 - P-loop containing dynein motor region D4 PF12781 - ATP-binding dynein motor region D5
ModBase Predicted Comparative 3D Structure on Q9P2D7-4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.