Human Gene DIPK2A (uc011bnl.2)
  Description: Homo sapiens chromosome 3 open reading frame 58 (DIPK2A), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:143,692,167-143,711,210 Size: 19,044 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr3:143,692,375-143,708,683 Size: 16,309 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:143,692,167-143,711,210)mRNA (may differ from genome)Protein (221 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVLynxMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.13 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 199.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.70208-0.282 Picture PostScript Text
3' UTR -568.842527-0.225 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF12260 - Protein-kinase domain of FAM69

ModBase Predicted Comparative 3D Structure on Q8NDZ4-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK315082 - Homo sapiens cDNA, FLJ96038.
BC037293 - Homo sapiens chromosome 3 open reading frame 58, mRNA (cDNA clone MGC:33365 IMAGE:5267770), complete cds.
HQ447256 - Synthetic construct Homo sapiens clone IMAGE:100070565; CCSB001993_01 chromosome 3 open reading frame 58 (C3orf58) gene, encodes complete protein.
KJ895823 - Synthetic construct Homo sapiens clone ccsbBroadEn_05217 C3orf58 gene, encodes complete protein.
AL832839 - Homo sapiens mRNA; cDNA DKFZp667B1925 (from clone DKFZp667B1925).
AK095161 - Homo sapiens cDNA FLJ37842 fis, clone BRSSN2012103.
AK294020 - Homo sapiens cDNA FLJ55179 complete cds.
AK095400 - Homo sapiens cDNA FLJ38081 fis, clone CTONG2016217.
AK095063 - Homo sapiens cDNA FLJ37744 fis, clone BRHIP2022326.
JD449211 - Sequence 430235 from Patent EP1572962.
JD337399 - Sequence 318423 from Patent EP1572962.
JD219270 - Sequence 200294 from Patent EP1572962.
JD093444 - Sequence 74468 from Patent EP1572962.
AK025119 - Homo sapiens cDNA: FLJ21466 fis, clone COL04842, highly similar to AF127481 Homo sapiens non-ocogenic Rho GTPase-specific GTP exchange factor (proto-LBC) mRNA.
JD302612 - Sequence 283636 from Patent EP1572962.
JD042453 - Sequence 23477 from Patent EP1572962.
JD520991 - Sequence 502015 from Patent EP1572962.
JD268680 - Sequence 249704 from Patent EP1572962.
JD311525 - Sequence 292549 from Patent EP1572962.
JD501724 - Sequence 482748 from Patent EP1572962.
JD296543 - Sequence 277567 from Patent EP1572962.
JD452446 - Sequence 433470 from Patent EP1572962.
JD553447 - Sequence 534471 from Patent EP1572962.
JD350666 - Sequence 331690 from Patent EP1572962.
JD226019 - Sequence 207043 from Patent EP1572962.
JD563439 - Sequence 544463 from Patent EP1572962.
JD244829 - Sequence 225853 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C3orf58, DIA1, NM_001134470, NP_001127942, Q8NDZ4-2
UCSC ID: uc011bnl.2
RefSeq Accession: NM_001134470
Protein: Q8NDZ4-2, splice isoform of Q8NDZ4 CCDS: CCDS46929.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001134470.1
exon count: 3CDS single in 3' UTR: no RNA size: 3416
ORF size: 666CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1532.00frame shift in genome: no % Coverage: 99.56
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.