Description: Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic (HTR3D), transcript variant 3, mRNA. RefSeq Summary (NM_001163646): The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]. Transcript (Including UTRs) Position: hg19 chr3:183,750,619-183,757,157 Size: 6,539 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr3:183,750,619-183,756,763 Size: 6,145 Coding Exon Count: 8
ID:5HT3D_HUMAN DESCRIPTION: RecName: Full=5-hydroxytryptamine receptor 3D; Short=5-HT3-D; Short=5-HT3D; AltName: Full=Serotonin receptor 3D; Flags: Precursor; FUNCTION: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. SUBUNIT: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. TISSUE SPECIFICITY: Expressed in liver, as well as fetal and adult colon and kidney. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q70Z44
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005515 protein binding GO:0022850 serotonin-gated cation channel activity
Biological Process: GO:0006811 ion transport GO:0007165 signal transduction GO:0007210 serotonin receptor signaling pathway GO:0034220 ion transmembrane transport
AY159812 - Homo sapiens 5-hydroxytryptamine serotonin receptor 3D (HTR3D) mRNA, complete cds. AJ437318 - Homo sapiens mRNA for 5-hydroxytryptamine 3-receptor subunit D (HTR3D gene). BC101090 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3 family member D, mRNA (cDNA clone MGC:119636 IMAGE:40009594), complete cds. BC101091 - Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3 family member D, mRNA (cDNA clone MGC:119637 IMAGE:40009597), complete cds. KJ903989 - Synthetic construct Homo sapiens clone ccsbBroadEn_13383 HTR3D gene, encodes complete protein.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q70Z44 (Reactome details) participates in the following event(s):
R-HSA-975311 HTR3 pentamer:5HT transports Na+,K+, and Ca2+ R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System