Human Gene OSTN (uc011bsn.2)
  Description: Homo sapiens osteocrin (OSTN), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:190,930,322-190,967,910 Size: 37,589 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr3:190,930,322-190,967,910 Size: 37,589 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:190,930,322-190,967,910)mRNA (may differ from genome)Protein (133 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OSTN_HUMAN
DESCRIPTION: RecName: Full=Osteocrin; AltName: Full=Musclin; Flags: Precursor;
FUNCTION: Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in bone.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): OSTN
CDC HuGE Published Literature: OSTN

-  MalaCards Disease Associations
  MalaCards Gene Search: OSTN
Diseases sorted by gene-association score: acromesomelic dysplasia (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.87 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 4.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021088 - Osteocrin

Pfam Domains:
PF11037 - Insulin-resistance promoting peptide in skeletal muscle

ModBase Predicted Comparative 3D Structure on P61366
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005179 hormone activity

Biological Process:
GO:0003416 endochondral bone growth
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organism development
GO:0010469 regulation of receptor activity
GO:0030154 cell differentiation
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0045668 negative regulation of osteoblast differentiation
GO:0046325 negative regulation of glucose import
GO:1903860 negative regulation of dendrite extension

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  KJ896099 - Synthetic construct Homo sapiens clone ccsbBroadEn_05493 OSTN gene, encodes complete protein.
AY398681 - Homo sapiens osteocrin protein precursor, mRNA, complete cds.
AY573933 - Homo sapiens musclin mRNA, complete cds.
BC128106 - Homo sapiens osteocrin, mRNA (cDNA clone MGC:149188 IMAGE:40112103), complete cds.
BC128107 - Homo sapiens osteocrin, mRNA (cDNA clone MGC:149189 IMAGE:40112104), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A1A4U3, NM_198184, NP_937827, OSTN_HUMAN, P61366
UCSC ID: uc011bsn.2
RefSeq Accession: NM_198184
Protein: P61366 (aka OSTN_HUMAN)
CCDS: CCDS3299.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198184.1
exon count: 3CDS single in 3' UTR: no RNA size: 402
ORF size: 402CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 904.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.