Human Gene AFAP1 (uc011bwk.1)
Description: Homo sapiens actin filament associated protein 1 (AFAP1), transcript variant A, mRNA.
RefSeq Summary (NM_001134647): The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Transcript (Including UTRs)
Position: hg19 chr4:7,760,440-7,941,653 Size: 181,214 Total Exon Count: 18 Strand: -
Coding Region
Position: hg19 chr4:7,765,492-7,873,805 Size: 108,314 Coding Exon Count: 17
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: E9PDT7_HUMAN
DESCRIPTION: SubName: Full=Actin filament-associated protein 1;
SIMILARITY: Contains 2 PH domains.CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
Pfam Domains: PF00169 - PH domain
SCOP Domains: 50729 - PH domain-like
ModBase Predicted Comparative 3D Structure on E9PDT7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AF188700 - Homo sapiens actin filament associated protein (AFAP) mRNA, complete cds.BC032777 - Homo sapiens actin filament associated protein 1, mRNA (cDNA clone MGC:44840 IMAGE:4914388), complete cds.AK297631 - Homo sapiens cDNA FLJ56849 complete cds, moderately similar to Mus musculus actin filament associated protein 1 (Afap1), mRNA.AK290807 - Homo sapiens cDNA FLJ75286 complete cds, highly similar to Homo sapiens actin filament associated protein (AFAP), transcript variant 1, mRNA.KJ899395 - Synthetic construct Homo sapiens clone ccsbBroadEn_08789 AFAP1 gene, encodes complete protein.AB527433 - Synthetic construct DNA, clone: pF1KE1022, Homo sapiens AFAP1 gene for actin filament associated protein 1, without stop codon, in Flexi system.CU689530 - Synthetic construct Homo sapiens gateway clone IMAGE:100017789 5' read AFAP1 mRNA.D25248 - Homo sapiens mRNA, clone: RES4-4.JD059176 - Sequence 40200 from Patent EP1572962.JD102985 - Sequence 84009 from Patent EP1572962.JD303897 - Sequence 284921 from Patent EP1572962.JD289395 - Sequence 270419 from Patent EP1572962.JD165712 - Sequence 146736 from Patent EP1572962.JD300188 - Sequence 281212 from Patent EP1572962.JD160044 - Sequence 141068 from Patent EP1572962.JD137910 - Sequence 118934 from Patent EP1572962.JD449931 - Sequence 430955 from Patent EP1572962.JD167378 - Sequence 148402 from Patent EP1572962.JD327644 - Sequence 308668 from Patent EP1572962.JD269435 - Sequence 250459 from Patent EP1572962.JD189405 - Sequence 170429 from Patent EP1572962.JD211324 - Sequence 192348 from Patent EP1572962.JD484835 - Sequence 465859 from Patent EP1572962.JD123842 - Sequence 104866 from Patent EP1572962.JD486525 - Sequence 467549 from Patent EP1572962.JD482820 - Sequence 463844 from Patent EP1572962.JD468302 - Sequence 449326 from Patent EP1572962.JD119651 - Sequence 100675 from Patent EP1572962.JD301193 - Sequence 282217 from Patent EP1572962.JD554414 - Sequence 535438 from Patent EP1572962.JD485555 - Sequence 466579 from Patent EP1572962.JD466113 - Sequence 447137 from Patent EP1572962.JD471255 - Sequence 452279 from Patent EP1572962.JD537795 - Sequence 518819 from Patent EP1572962.JD365804 - Sequence 346828 from Patent EP1572962.JD067695 - Sequence 48719 from Patent EP1572962.JD460739 - Sequence 441763 from Patent EP1572962.BC015900 - Homo sapiens, clone IMAGE:3909917, mRNA.JD192789 - Sequence 173813 from Patent EP1572962.DQ585763 - Homo sapiens piRNA piR-52875, complete sequence.JD459237 - Sequence 440261 from Patent EP1572962.JD498509 - Sequence 479533 from Patent EP1572962.JD318588 - Sequence 299612 from Patent EP1572962.JD176183 - Sequence 157207 from Patent EP1572962.JD488922 - Sequence 469946 from Patent EP1572962.JD155367 - Sequence 136391 from Patent EP1572962.JD367126 - Sequence 348150 from Patent EP1572962.JD036694 - Sequence 17718 from Patent EP1572962.JD292741 - Sequence 273765 from Patent EP1572962.JD336685 - Sequence 317709 from Patent EP1572962.JD164265 - Sequence 145289 from Patent EP1572962.JD183519 - Sequence 164543 from Patent EP1572962.JD106706 - Sequence 87730 from Patent EP1572962.JD452952 - Sequence 433976 from Patent EP1572962.JD349580 - Sequence 330604 from Patent EP1572962.JD133536 - Sequence 114560 from Patent EP1572962.JD193510 - Sequence 174534 from Patent EP1572962.JD134357 - Sequence 115381 from Patent EP1572962.JD231213 - Sequence 212237 from Patent EP1572962.JD278195 - Sequence 259219 from Patent EP1572962.JD398871 - Sequence 379895 from Patent EP1572962.JD518589 - Sequence 499613 from Patent EP1572962.JD372768 - Sequence 353792 from Patent EP1572962.DQ599547 - Homo sapiens piRNA piR-37613, complete sequence.JD212052 - Sequence 193076 from Patent EP1572962.JD415945 - Sequence 396969 from Patent EP1572962.JD345190 - Sequence 326214 from Patent EP1572962.JD096022 - Sequence 77046 from Patent EP1572962.JD202462 - Sequence 183486 from Patent EP1572962.JD380498 - Sequence 361522 from Patent EP1572962.JD494584 - Sequence 475608 from Patent EP1572962.JD474169 - Sequence 455193 from Patent EP1572962.JD288758 - Sequence 269782 from Patent EP1572962.AB209676 - Homo sapiens mRNA for actin filament associated protein variant protein.AK127962 - Homo sapiens cDNA FLJ46074 fis, clone TESTI2001915, highly similar to Homo sapiens actin filament associated protein (AFAP).JD179573 - Sequence 160597 from Patent EP1572962.JD253813 - Sequence 234837 from Patent EP1572962.JD438077 - Sequence 419101 from Patent EP1572962.JD342909 - Sequence 323933 from Patent EP1572962.JD242053 - Sequence 223077 from Patent EP1572962.JD146261 - Sequence 127285 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: E9PDT7, E9PDT7_HUMAN, NM_001134647, NP_001128119UCSC ID: uc011bwk.1RefSeq Accession: NM_001134647
Protein: E9PDT7
CCDS: CCDS47010.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001134647.1
exon count:
18 CDS single in 3' UTR:
no
RNA size:
7786
ORF size:
2445 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
4698.00 frame shift in genome:
no
% Coverage:
99.79
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.