Description: Homo sapiens coenzyme Q2 4-hydroxybenzoate polyprenyltransferase (COQ2), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_015697): This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]. Transcript (Including UTRs) Position: hg19 chr4:84,182,689-84,206,067 Size: 23,379 Total Exon Count: 7 Strand: -
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK300972 - Homo sapiens cDNA FLJ61421 complete cds, highly similar to Para-hydroxybenzoate--polyprenyltransferase, mitochondrial precursor (EC 2.5.1.-). BC116454 - Homo sapiens coenzyme Q2 homolog, prenyltransferase (yeast), mRNA (cDNA clone IMAGE:6016926), partial cds. AF091086 - Homo sapiens clone 640 unknown mRNA, complete sequence. BC008804 - Homo sapiens coenzyme Q2 homolog, prenyltransferase (yeast), mRNA (cDNA clone MGC:10413 IMAGE:3954787), complete cds. KU877220 - Homo sapiens coenzyme Q2 mRNA, complete cds. AK129583 - Homo sapiens cDNA FLJ26072 fis, clone RCT01281. BC020728 - Homo sapiens coenzyme Q2 homolog, prenyltransferase (yeast), mRNA (cDNA clone MGC:22534 IMAGE:4696019), complete cds. AJ621061 - Homo sapiens mRNA for para-hydroxybenzoate--polyprenyltransferase, mitochondrial precursor (COQ2 gene). EU176380 - Synthetic construct Homo sapiens clone IMAGE:100006477; FLH188861.01X; RZPDo839F12251D coenzyme Q2 homolog, prenyltransferase (yeast) (COQ2) gene, encodes complete protein. DQ895928 - Synthetic construct Homo sapiens clone IMAGE:100010388; FLH188854.01L; RZPDo839G1063D coenzyme Q2 homolog, prenyltransferase (yeast) (COQ2) gene, encodes complete protein. CR456860 - Homo sapiens full open reading frame cDNA clone RZPDo834F0515D for gene CL640, hypothetical protein CL640; complete cds, incl. stopcodon. AK023076 - Homo sapiens cDNA FLJ13014 fis, clone NT2RP3000592.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00130 - Ubiquinone and other terpenoid-quinone biosynthesis hsa01100 - Metabolic pathways