Description: Homo sapiens SEC24 family, member B (S. cerevisiae) (SEC24B), transcript variant 2, mRNA. RefSeq Summary (NM_001042734): The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. Transcript (Including UTRs) Position: hg19 chr4:110,354,971-110,461,615 Size: 106,645 Total Exon Count: 23 Strand: + Coding Region Position: hg19 chr4:110,355,026-110,460,831 Size: 105,806 Coding Exon Count: 23
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81811 - Helical domain of Sec23/24 81995 - beta-sandwich domain of Sec23/24 53300 - vWA-like 55753 - Actin depolymerizing proteins 82754 - C-terminal, gelsolin-like domain of Sec23/24 82919 - Zn-finger domain of Sec23/24
ModBase Predicted Comparative 3D Structure on O95487-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AJ131245 - Homo sapiens mRNA for Sec24 protein (Sec24B isoform). BC143268 - Homo sapiens SEC24 family, member B (S. cerevisiae), mRNA (cDNA clone MGC:176787 IMAGE:9051770), complete cds. BC117135 - Homo sapiens SEC24 family, member B (S. cerevisiae), mRNA (cDNA clone MGC:150744 IMAGE:40125686), complete cds. BC143269 - Homo sapiens cDNA clone IMAGE:9051771, containing frame-shift errors. BC143276 - Homo sapiens SEC24 family, member B (S. cerevisiae), mRNA (cDNA clone MGC:176795 IMAGE:9051778), complete cds. BC040137 - Homo sapiens SEC24 family, member B (S. cerevisiae), mRNA (cDNA clone MGC:48822 IMAGE:5492331), complete cds. AK300278 - Homo sapiens cDNA FLJ61391 complete cds, highly similar to Protein transport protein Sec24B. JD132712 - Sequence 113736 from Patent EP1572962. AK304234 - Homo sapiens cDNA FLJ54322 complete cds, highly similar to Protein transport protein Sec24B. JD518262 - Sequence 499286 from Patent EP1572962. JD501865 - Sequence 482889 from Patent EP1572962. JD430721 - Sequence 411745 from Patent EP1572962. JD226313 - Sequence 207337 from Patent EP1572962. JD508599 - Sequence 489623 from Patent EP1572962. JD509253 - Sequence 490277 from Patent EP1572962. JD157838 - Sequence 138862 from Patent EP1572962. JD490659 - Sequence 471683 from Patent EP1572962. JD200098 - Sequence 181122 from Patent EP1572962. JD156685 - Sequence 137709 from Patent EP1572962. JD301103 - Sequence 282127 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95487 (Reactome details) participates in the following event(s):
US Server
