Description: Homo sapiens integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2), transcript variant 6, non-coding RNA. RefSeq Summary (NR_073107): This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. Transcript (Including UTRs) Position: hg19 chr5:52,285,156-52,390,609 Size: 105,454 Total Exon Count: 29 Strand: + Coding Region Position: hg19 chr5:52,337,985-52,386,429 Size: 48,445 Coding Exon Count: 28
ID:ITA2_HUMAN DESCRIPTION: RecName: Full=Integrin alpha-2; AltName: Full=CD49 antigen-like family member B; AltName: Full=Collagen receptor; AltName: Full=Platelet membrane glycoprotein Ia; Short=GPIa; AltName: Full=VLA-2 subunit alpha; AltName: CD_antigen=CD49b; Flags: Precursor; FUNCTION: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor. INTERACTION: P05556:ITGB1; NbExp=3; IntAct=EBI-702960, EBI-703066; P35282:Rab21 (xeno); NbExp=7; IntAct=EBI-702960, EBI-1993555; Q9H0F6:SHARPIN; NbExp=5; IntAct=EBI-702960, EBI-3942966; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. POLYMORPHISM: Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD). SIMILARITY: Belongs to the integrin alpha chain family. SIMILARITY: Contains 7 FG-GAP repeats. SIMILARITY: Contains 1 VWFA domain. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ITGA2"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/itga2/";
atherosclerosis, coronary; hematology indices Ajzenberg, N. et al. 2005, Association of the -92C/G and 807C/T polymorphisms of the alpha2 subunit gene with human platelets alpha2beta1 receptor density., Arteriosclerosis, thrombosis, and vascular biology. 2005 Aug;25(8):1756-60.
[PubMed 15947241]
These results suggest that an individual effect of each polymorphism located either in the coding or promoter sequence of the alpha2 gene may act in combination to modulate variations in platelets alpha2beta1 receptor density.
Behcet's Disease Polat G et al. 2002, Association of the platelet glycoprotein Ia C807T/G873A gene polymorphism and thrombosis in Behcet patients., Haematologia. 2002 ;32(2):121-8.
[PubMed 12412731]
Our data indicate hat patients with BD are affected by the glycoprotein Ia gene 807TT genotypes and carrying 807T allele. The risk of thrombosis is significantly higher in patients who have 807TT and 807CT genotypes than in patients who have 807CC genotype.
bleeding complications Welsby, I. J. et al. 2005, Genetic factors contribute to bleeding after cardiac surgery., Journal of thrombosis and haemostasis. 2005 Jun;3(6):1206-12.
[PubMed 15892865]
We identified seven genetic polymorphisms associated with bleeding after cardiac surgery. Genetic factors appear primarily independent of, and explain at least as much variation in bleeding as clinical covariates; combining genetic and clinical factors double our ability to predict bleeding after cardiac surgery. Accounting for genotype may be necessary when stratifying risk of bleeding after cardiac surgery.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00092 - von Willebrand factor type A domain PF00357 - Integrin alpha cytoplasmic region PF01839 - FG-GAP repeat PF08441 - Integrin alpha PF13519 - von Willebrand factor type A domain
ModBase Predicted Comparative 3D Structure on P17301
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
