Human Gene PPWD1 (uc011cqv.3)
Description: Homo sapiens peptidylprolyl isomerase domain and WD repeat containing 1 (PPWD1), transcript variant 2, non-coding RNA.Transcript (Including UTRs) Position: hg19 chr5:64,859,063-64,883,376 Size: 24,314 Total Exon Count: 12 Strand: +Coding Region Position: hg19 chr5:64,859,265-64,883,223 Size: 23,959 Coding Exon Count: 12
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: F5H7P7_HUMAN DESCRIPTION: SubName: Full=Peptidylprolyl isomerase domain and WD repeat-containing protein 1;SIMILARITY: Contains 1 PPIase cyclophilin-type domain.CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002130 - Cyclophilin-like_PPIase_domIPR015943 - WD40/YVTN_repeat-like_domIPR001680 - WD40_repeatIPR017986 - WD40_repeat_domPfam Domains: PF00160 - Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDPF00400 - WD domain, G-beta repeatSCOP Domains: 50891 - Cyclophilin-like50952 - Soluble quinoprotein glucose dehydrogenase50960 - TolB, C-terminal domain63829 - Calcium-dependent phosphotriesterase69304 - Tricorn protease N-terminal domain101898 - NHL repeat50965 - Galactose oxidase, central domain75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme101908 - Putative isomerase YbhE50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase50974 - Nitrous oxide reductase, N-terminal domain50978 - WD40 repeat-like50993 - Prolyl oligopeptidase, N-terminal domain69322 - Tricorn protease domain 251004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase82171 - Dipeptidyl peptidase IV/CD26, N-terminal domainModBase Predicted Comparative 3D Structure on F5H7P7 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog Gene Details Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003755 peptidyl-prolyl cis-trans isomerase activityGO:0016853 isomerase activityBiological Process: GO:0000413 protein peptidyl-prolyl isomerizationCellular Component: GO:0016604 nuclear body
Descriptions from all associated GenBank mRNAs
LF209896 - JP 2014500723-A/17399: Polycomb-Associated Non-Coding RNAs.AK025679 - Homo sapiens cDNA: FLJ22026 fis, clone HEP08537.AK300022 - Homo sapiens cDNA FLJ53187 complete cds, highly similar to Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).AK301654 - Homo sapiens cDNA FLJ53227 complete cds, highly similar to Peptidylprolyl isomerase domain and WDrepeat-containing protein 1 (EC 5.2.1.8).AK298175 - Homo sapiens cDNA FLJ53149 complete cds, highly similar to Peptidylprolyl isomerase domain and WDrepeat-containing protein 1 (EC 5.2.1.8).BC015385 - Homo sapiens peptidylprolyl isomerase domain and WD repeat containing 1, mRNA (cDNA clone MGC:21685 IMAGE:4390706), complete cds.GQ891478 - Homo sapiens clone HEL-S-199 epididymis secretory sperm binding protein mRNA, complete cds.AB384434 - Synthetic construct DNA, clone: pF1KA0073, Homo sapiens PPWD1 gene for peptidylprolyl isomerase domain and WD repeat-containing protein 1, complete cds, without stop codon, in Flexi system.GQ129262 - Synthetic construct Homo sapiens clone HAIB:100068663; DKFZo004C0136 peptidylprolyl isomerase domain and WD repeat containing 1 protein (PPWD1) gene, partial cds.GQ129263 - Synthetic construct Homo sapiens clone HAIB:100068566; DKFZo008C0135 peptidylprolyl isomerase domain and WD repeat containing 1 protein (PPWD1) gene, complete cds.KJ898483 - Synthetic construct Homo sapiens clone ccsbBroadEn_07877 PPWD1 gene, encodes complete protein.D38552 - Homo sapiens KIAA0073 mRNA, partial cds.MA445473 - JP 2018138019-A/17399: Polycomb-Associated Non-Coding RNAs.AK093675 - Homo sapiens cDNA FLJ36356 fis, clone THYMU2007415.CU677289 - Synthetic construct Homo sapiens gateway clone IMAGE:100020763 5' read PPWD1 mRNA.LF332513 - JP 2014500723-A/140016: Polycomb-Associated Non-Coding RNAs.LF332511 - JP 2014500723-A/140014: Polycomb-Associated Non-Coding RNAs.LF332508 - JP 2014500723-A/140011: Polycomb-Associated Non-Coding RNAs.MA568090 - JP 2018138019-A/140016: Polycomb-Associated Non-Coding RNAs.MA568088 - JP 2018138019-A/140014: Polycomb-Associated Non-Coding RNAs.MA568085 - JP 2018138019-A/140011: Polycomb-Associated Non-Coding RNAs.AK057718 - Homo sapiens cDNA FLJ33156 fis, clone UTERU2000377, weakly similar to PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C57A10.03 (EC 5.2.1.8).LF332506 - JP 2014500723-A/140009: Polycomb-Associated Non-Coding RNAs.MA568083 - JP 2018138019-A/140009: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: F5H7P7, F5H7P7_HUMAN, NR_046348, uc011cqv.2UCSC ID: uc011cqv.3RefSeq Accession: NR_046348 Protein: F5H7P7
CCDS: CCDS64161.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NR_046348.1
exon count:
12 CDS single in 3' UTR:
no
RNA size:
2223 ORF size:
1851 CDS single in intron:
no
Alignment % ID:
100.00 txCdsPredict score:
3764.00 frame shift in genome:
no
% Coverage:
99.24 has start codon:
yes
stop codon in genome:
no
# of Alignments:
1 has end codon:
yes
retained intron:
no
# AT/AC introns
0 selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
