Human Gene NREP (uc011cvm.2)
  Description: Homo sapiens neuronal regeneration related protein (NREP), transcript variant 7, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:111,065,000-111,093,252 Size: 28,253 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr5:111,066,618-111,091,469 Size: 24,852 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:111,065,000-111,093,252)mRNA (may differ from genome)Protein (68 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NREP_HUMAN
DESCRIPTION: RecName: Full=Neuronal regeneration-related protein; AltName: Full=Neuronal protein 3.1; AltName: Full=Protein p311;
FUNCTION: May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity).
SUBUNIT: Interacts with FLNA.
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NREP
Diseases sorted by gene-association score: rett syndrome (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 89.16 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 346.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -99.91280-0.357 Picture PostScript Text
3' UTR -428.511618-0.265 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024417 - Neuronal_3.1

Pfam Domains:
PF11092 - Neuronal protein 3.1 (p311)

ModBase Predicted Comparative 3D Structure on Q16612
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK298779 - Homo sapiens cDNA FLJ55239 complete cds, moderately similar to Neuronal protein 3.1.
BX649051 - Homo sapiens mRNA; cDNA DKFZp779C2250 (from clone DKFZp779C2250).
AK307346 - Homo sapiens cDNA, FLJ97294.
U30521 - Human P311 HUM (3.1) mRNA, complete cds.
AF119859 - Homo sapiens PRO1873 mRNA, complete cds.
BC019068 - Homo sapiens chromosome 5 open reading frame 13, mRNA (cDNA clone MGC:29555 IMAGE:4893075), complete cds.
BC001783 - Homo sapiens mRNA similar to ribosomal protein L35a (cDNA clone IMAGE:3355533).
BC072013 - Homo sapiens chromosome 5 open reading frame 13, mRNA (cDNA clone MGC:88723 IMAGE:5922876), complete cds.
BC072443 - Homo sapiens chromosome 5 open reading frame 13, mRNA (cDNA clone MGC:87994 IMAGE:6162335), complete cds.
BC011050 - Homo sapiens chromosome 5 open reading frame 13, mRNA (cDNA clone MGC:17077 IMAGE:4340005), complete cds.
JD114509 - Sequence 95533 from Patent EP1572962.
JD313636 - Sequence 294660 from Patent EP1572962.
JD454977 - Sequence 436001 from Patent EP1572962.
JD404953 - Sequence 385977 from Patent EP1572962.
JD483352 - Sequence 464376 from Patent EP1572962.
JD338408 - Sequence 319432 from Patent EP1572962.
JD250054 - Sequence 231078 from Patent EP1572962.
JD450466 - Sequence 431490 from Patent EP1572962.
JD512344 - Sequence 493368 from Patent EP1572962.
AK309667 - Homo sapiens cDNA, FLJ99708.
JD521352 - Sequence 502376 from Patent EP1572962.
JD553702 - Sequence 534726 from Patent EP1572962.
JD173008 - Sequence 154032 from Patent EP1572962.
JD172689 - Sequence 153713 from Patent EP1572962.
JD345893 - Sequence 326917 from Patent EP1572962.
JD089731 - Sequence 70755 from Patent EP1572962.
JD197719 - Sequence 178743 from Patent EP1572962.
U36189 - Human p311 protein (hP311) mRNA, complete cds.
JD301842 - Sequence 282866 from Patent EP1572962.
JD267835 - Sequence 248859 from Patent EP1572962.
JD023137 - Sequence 4161 from Patent EP1572962.
AK315617 - Homo sapiens cDNA, FLJ96698.
KJ892740 - Synthetic construct Homo sapiens clone ccsbBroadEn_02134 NREP gene, encodes complete protein.
JD030065 - Sequence 11089 from Patent EP1572962.
JD020451 - Sequence 1475 from Patent EP1572962.
AK310585 - Homo sapiens cDNA, FLJ17627.
JD400477 - Sequence 381501 from Patent EP1572962.
JD400476 - Sequence 381500 from Patent EP1572962.
JD416777 - Sequence 397801 from Patent EP1572962.
JD204915 - Sequence 185939 from Patent EP1572962.
JD339591 - Sequence 320615 from Patent EP1572962.
JD224956 - Sequence 205980 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDN8, B7Z5D2, C5orf13, D3DSZ8, NM_001142479, NP_004763, NREP_HUMAN, P311, Q16612
UCSC ID: uc011cvm.2
RefSeq Accession: NM_001142479
Protein: Q16612 (aka NREP_HUMAN)
CCDS: CCDS4105.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001142479.1
exon count: 5CDS single in 3' UTR: no RNA size: 2105
ORF size: 207CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 614.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.