Description: Homo sapiens annexin A6 (ANXA6), transcript variant 2, mRNA. RefSeq Summary (NM_001193544): Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]. Transcript (Including UTRs) Position: hg19 chr5:150,480,267-150,521,216 Size: 40,950 Total Exon Count: 25 Strand: - Coding Region Position: hg19 chr5:150,481,009-150,519,726 Size: 38,718 Coding Exon Count: 24
ID:ANXA6_HUMAN DESCRIPTION: RecName: Full=Annexin A6; AltName: Full=67 kDa calelectrin; AltName: Full=Annexin VI; AltName: Full=Annexin-6; AltName: Full=Calphobindin-II; Short=CPB-II; AltName: Full=Chromobindin-20; AltName: Full=Lipocortin VI; AltName: Full=Protein III; AltName: Full=p68; AltName: Full=p70; FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. INDUCTION: By Epstein-Barr virus (EBV). DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid. PTM: Phosphorylated in response to growth factor stimulation. MISCELLANEOUS: Seems to bind one calcium ion with high affinity. SIMILARITY: Belongs to the annexin family. SIMILARITY: Contains 8 annexin repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08133
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006816 calcium ion transport GO:0006937 regulation of muscle contraction GO:0034220 ion transmembrane transport GO:0051260 protein homooligomerization GO:0051560 mitochondrial calcium ion homeostasis GO:0097190 apoptotic signaling pathway