The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15213
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC000388 - Homo sapiens WD repeat domain 46, mRNA (cDNA clone MGC:8435 IMAGE:2821198), complete cds. AF447870 - Homo sapiens FP221 mRNA, complete cds. AK297925 - Homo sapiens cDNA FLJ51004 complete cds, highly similar to WD repeat protein 46. AK292616 - Homo sapiens cDNA FLJ77639 complete cds. AK292171 - Homo sapiens cDNA FLJ77705 complete cds. JD222501 - Sequence 203525 from Patent EP1572962. JD203161 - Sequence 184185 from Patent EP1572962. JD539121 - Sequence 520145 from Patent EP1572962. JD555091 - Sequence 536115 from Patent EP1572962. JD305229 - Sequence 286253 from Patent EP1572962. JD323217 - Sequence 304241 from Patent EP1572962. AK298151 - Homo sapiens cDNA FLJ51014 complete cds, highly similar to WD repeat protein 46. JD221069 - Sequence 202093 from Patent EP1572962. JD078187 - Sequence 59211 from Patent EP1572962. AK315616 - Homo sapiens cDNA, FLJ96697. KJ897991 - Synthetic construct Homo sapiens clone ccsbBroadEn_07385 WDR46 gene, encodes complete protein. AK311388 - Homo sapiens cDNA, FLJ18430. AK308534 - Homo sapiens cDNA, FLJ98575. CU674188 - Synthetic construct Homo sapiens gateway clone IMAGE:100017738 5' read WDR46 mRNA. JD460716 - Sequence 441740 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O15213 (Reactome details) participates in the following event(s):
R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-72312 rRNA processing R-HSA-8953854 Metabolism of RNA