Description: Homo sapiens tight junction associated protein 1 (peripheral) (TJAP1), transcript variant 2, mRNA. RefSeq Summary (NM_001146017): This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]. Transcript (Including UTRs) Position: hg19 chr6:43,457,322-43,474,294 Size: 16,973 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr6:43,466,740-43,473,593 Size: 6,854 Coding Exon Count: 8
ID:TJAP1_HUMAN DESCRIPTION: RecName: Full=Tight junction-associated protein 1; AltName: Full=Protein incorporated later into tight junctions; AltName: Full=Tight junction protein 4; SUBUNIT: Interacts with DLG1. SUBCELLULAR LOCATION: Golgi apparatus (By similarity). Cell junction, tight junction (By similarity). Note=Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from adherens junctions and desmosomes (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF15453 - Protein incorporated later into Tight Junctions
ModBase Predicted Comparative 3D Structure on Q5JTD0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
