Description: Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1), transcript variant 2, mRNA. RefSeq Summary (NM_013993): Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]. Transcript (Including UTRs) Position: hg19 chr6_cox_hap2:2,364,413-2,380,033 Size: 15,621 Total Exon Count: 18 Strand: + Coding Region Position: hg19 chr6_cox_hap2:2,368,605-2,379,173 Size: 10,569 Coding Exon Count: 17
ID:DDR1_HUMAN DESCRIPTION: RecName: Full=Epithelial discoidin domain-containing receptor 1; Short=Epithelial discoidin domain receptor 1; EC=2.7.10.1; AltName: Full=CD167 antigen-like family member A; AltName: Full=Cell adhesion kinase; AltName: Full=Discoidin receptor tyrosine kinase; AltName: Full=HGK2; AltName: Full=Mammary carcinoma kinase 10; Short=MCK-10; AltName: Full=Protein-tyrosine kinase 3A; AltName: Full=Protein-tyrosine kinase RTK-6; AltName: Full=TRK E; AltName: Full=Tyrosine kinase DDR; AltName: Full=Tyrosine-protein kinase CAK; AltName: CD_antigen=CD167a; Flags: Precursor; FUNCTION: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 3: Secreted (Potential). SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin. DOMAIN: The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates. PTM: Autophosphorylated in response to fibrillar collagen binding. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. SIMILARITY: Contains 1 F5/8 type C domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=ACF47649.1; Type=Erroneous termination; Positions=287; Note=Translated as Cys; Sequence=BAE06103.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08345
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF210805 - JP 2014500723-A/18308: Polycomb-Associated Non-Coding RNAs. AK291621 - Homo sapiens cDNA FLJ75091 complete cds, highly similar to Homo sapiens discoidin domain receptor family, member 1 (DDR1),transcript variant 2, mRNA. BC008716 - Homo sapiens discoidin domain receptor tyrosine kinase 1, mRNA (cDNA clone MGC:8681 IMAGE:2964574), complete cds. BC013400 - Homo sapiens discoidin domain receptor tyrosine kinase 1, mRNA (cDNA clone MGC:3909 IMAGE:2964574), complete cds. L20817 - Homo sapiens tyrosine protein kinase (CAK) gene, complete cds. L57508 - Homo sapiens Cak receptor kinase mRNA, complete cds. BC070070 - Homo sapiens discoidin domain receptor tyrosine kinase 1, mRNA (cDNA clone MGC:87336 IMAGE:5262509), complete cds. AB210021 - Homo sapiens mRNA for DDR1 variant protein, clone: fk11093. L11315 - Homo sapiens receptor tyrosine kinase mRNA, complete cds. AK294793 - Homo sapiens cDNA FLJ56035 complete cds, highly similar to Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1). AK295643 - Homo sapiens cDNA FLJ54797 complete cds, highly similar to Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1). Z29093 - H.sapiens EDDR1 gene for receptor tyrosine kinase. X74979 - H.sapiens TRK E mRNA. JD075742 - Sequence 56766 from Patent EP1572962. EU826614 - Homo sapiens soluble DDR1 variant 2 (DDR1) mRNA, complete cds, alternatively spliced. EU826613 - Homo sapiens soluble DDR1 variant 1 (DDR1) mRNA, complete cds, alternatively spliced. CU687028 - Synthetic construct Homo sapiens gateway clone IMAGE:100022861 5' read DDR1 mRNA. AB463012 - Synthetic construct DNA, clone: pF1KB2260, Homo sapiens DDR1 gene for discoidin domain receptor tyrosine kinase 1, without stop codon, in Flexi system. KJ896529 - Synthetic construct Homo sapiens clone ccsbBroadEn_05923 DDR1 gene, encodes complete protein. LF341301 - JP 2014500723-A/148804: Polycomb-Associated Non-Coding RNAs. AK130776 - Homo sapiens cDNA FLJ27266 fis, clone TMS00356, highly similar to Epithelial discoidin domain receptor 1 precursor (EC 2.7.1.112). LF341299 - JP 2014500723-A/148802: Polycomb-Associated Non-Coding RNAs. AF353182 - Homo sapiens discoidin domain receptor DDR1d (DDR1) mRNA, partial cds, alternatively spliced. AF353183 - Homo sapiens discoidin domain receptor DDR1e (DDR1) mRNA, partial cds, alternatively spliced. LF341297 - JP 2014500723-A/148800: Polycomb-Associated Non-Coding RNAs. JD052337 - Sequence 33361 from Patent EP1572962. LF341296 - JP 2014500723-A/148799: Polycomb-Associated Non-Coding RNAs. JD193042 - Sequence 174066 from Patent EP1572962. JD174498 - Sequence 155522 from Patent EP1572962. JD156428 - Sequence 137452 from Patent EP1572962. JD218441 - Sequence 199465 from Patent EP1572962. JD155244 - Sequence 136268 from Patent EP1572962. JD112692 - Sequence 93716 from Patent EP1572962. JD547231 - Sequence 528255 from Patent EP1572962. JD448039 - Sequence 429063 from Patent EP1572962. JD460373 - Sequence 441397 from Patent EP1572962. JD508253 - Sequence 489277 from Patent EP1572962. JD200513 - Sequence 181537 from Patent EP1572962. JD537942 - Sequence 518966 from Patent EP1572962. JD405714 - Sequence 386738 from Patent EP1572962. JD387885 - Sequence 368909 from Patent EP1572962. JD117888 - Sequence 98912 from Patent EP1572962. JD353717 - Sequence 334741 from Patent EP1572962. JD544426 - Sequence 525450 from Patent EP1572962. JD434185 - Sequence 415209 from Patent EP1572962. JD294504 - Sequence 275528 from Patent EP1572962. JD555541 - Sequence 536565 from Patent EP1572962. JD128731 - Sequence 109755 from Patent EP1572962. JD387522 - Sequence 368546 from Patent EP1572962. JD539743 - Sequence 520767 from Patent EP1572962. JD470204 - Sequence 451228 from Patent EP1572962. LF341295 - JP 2014500723-A/148798: Polycomb-Associated Non-Coding RNAs. MA446382 - JP 2018138019-A/18308: Polycomb-Associated Non-Coding RNAs. MA576878 - JP 2018138019-A/148804: Polycomb-Associated Non-Coding RNAs. MA576876 - JP 2018138019-A/148802: Polycomb-Associated Non-Coding RNAs. MA576874 - JP 2018138019-A/148800: Polycomb-Associated Non-Coding RNAs. MA576873 - JP 2018138019-A/148799: Polycomb-Associated Non-Coding RNAs. MA576872 - JP 2018138019-A/148798: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q08345 (Reactome details) participates in the following event(s):
R-HSA-2327738 DDR1 binds collagen type I, II, III, IV, V, XI fibrils R-HSA-3000171 Non-integrin membrane-ECM interactions R-HSA-1474244 Extracellular matrix organization
US Server
