Description: Homo sapiens vacuolar protein sorting 52 homolog (S. cerevisiae) (VPS52), mRNA. RefSeq Summary (NM_022553): This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Transcript (Including UTRs) Position: hg19 chr6_cox_hap2:4,661,875-4,683,549 Size: 21,675 Total Exon Count: 18 Strand: - Coding Region Position: hg19 chr6_cox_hap2:4,662,444-4,680,773 Size: 18,330 Coding Exon Count: 13
ID:VPS52_HUMAN DESCRIPTION: RecName: Full=Vacuolar protein sorting-associated protein 52 homolog; AltName: Full=SAC2 suppressor of actin mutations 2-like protein; FUNCTION: May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. SUBUNIT: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts with RAB6A and STX10. SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. SIMILARITY: Belongs to the VPS52 family. SEQUENCE CAUTION: Sequence=CAI95619.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N1B4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006896 Golgi to vacuole transport GO:0007041 lysosomal transport GO:0010668 ectodermal cell differentiation GO:0015031 protein transport GO:0032456 endocytic recycling GO:0042147 retrograde transport, endosome to Golgi GO:0048611 embryonic ectodermal digestive tract development
AK222867 - Homo sapiens mRNA for suppressor of actin mutations 2-like isoform a variant, clone: HEP15548. BC032108 - Homo sapiens vacuolar protein sorting 52 homolog (S. cerevisiae), mRNA (cDNA clone MGC:23328 IMAGE:4644275), complete cds. BC040114 - Homo sapiens vacuolar protein sorting 52 homolog (S. cerevisiae), mRNA (cDNA clone MGC:48686 IMAGE:5755265), complete cds. AK093057 - Homo sapiens cDNA FLJ35738 fis, clone TESTI2003692, highly similar to Rattus norvegicus mRNA for ARE1 protein. AK001725 - Homo sapiens cDNA FLJ10863 fis, clone NT2RP4001575, highly similar to Vacuolar protein sorting protein 52. AL390171 - Homo sapiens mRNA; cDNA DKFZp547I194 (from clone DKFZp547I194). AX775737 - Sequence 7 from Patent WO03048202. JD390645 - Sequence 371669 from Patent EP1572962. BC013012 - Homo sapiens vacuolar protein sorting 52 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3605512), **** WARNING: chimeric clone ****. JD566807 - Sequence 547831 from Patent EP1572962. JD291127 - Sequence 272151 from Patent EP1572962. JD221489 - Sequence 202513 from Patent EP1572962. JD220086 - Sequence 201110 from Patent EP1572962. JD218811 - Sequence 199835 from Patent EP1572962. JD465985 - Sequence 447009 from Patent EP1572962. JD454888 - Sequence 435912 from Patent EP1572962. AK299563 - Homo sapiens cDNA FLJ55499 complete cds, highly similar to Vacuolar protein sorting protein 52. JD501814 - Sequence 482838 from Patent EP1572962. JD528811 - Sequence 509835 from Patent EP1572962. JD290021 - Sequence 271045 from Patent EP1572962. AK297935 - Homo sapiens cDNA FLJ54452 complete cds, highly similar to Vacuolar protein sorting protein 52. AJ006026 - Homo sapiens mRNA for ARE1-like protein. JD554294 - Sequence 535318 from Patent EP1572962. JD391240 - Sequence 372264 from Patent EP1572962. JD365615 - Sequence 346639 from Patent EP1572962. JD149911 - Sequence 130935 from Patent EP1572962. JD020325 - Sequence 1349 from Patent EP1572962. JD021665 - Sequence 2689 from Patent EP1572962. JD031297 - Sequence 12321 from Patent EP1572962. AK304080 - Homo sapiens cDNA FLJ58349 complete cds, highly similar to Vacuolar protein sorting protein 52. AK300430 - Homo sapiens cDNA FLJ60156 complete cds, highly similar to Vacuolar protein sorting protein 52. AK300308 - Homo sapiens cDNA FLJ58858 complete cds, highly similar to Vacuolar protein sorting protein 52.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8N1B4 (Reactome details) participates in the following event(s):
R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6814674 Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
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