Description: Homo sapiens activating transcription factor 6 beta (ATF6B), transcript variant 1, mRNA. RefSeq Summary (NM_004381): The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]. Transcript (Including UTRs) Position: hg19 chr6_mcf_hap5:3,462,873-3,475,845 Size: 12,973 Total Exon Count: 18 Strand: - Coding Region Position: hg19 chr6_mcf_hap5:3,463,344-3,475,812 Size: 12,469 Coding Exon Count: 18
ID:ATF6B_HUMAN DESCRIPTION: RecName: Full=Cyclic AMP-dependent transcription factor ATF-6 beta; Short=cAMP-dependent transcription factor ATF-6 beta; AltName: Full=Activating transcription factor 6 beta; Short=ATF6-beta; AltName: Full=Protein G13; AltName: Full=cAMP response element-binding protein-related protein; Short=Creb-rp; AltName: Full=cAMP-responsive element-binding protein-like 1; Contains: RecName: Full=Processed cyclic AMP-dependent transcription factor ATF-6 beta; FUNCTION: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. SUBUNIT: Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: Processed cyclic AMP-dependent transcription factor ATF-6 beta: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The basic domain functions as a nuclear localization signal. DOMAIN: The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. PTM: N-glycosylated. PTM: During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases. SIMILARITY: Belongs to the bZIP family. ATF subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. SEQUENCE CAUTION: Sequence=AAC50888.1; Type=Frameshift; Positions=600; Sequence=AAG14898.1; Type=Frameshift; Positions=600;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99941
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0035497 cAMP response element binding GO:0044212 transcription regulatory region DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006986 response to unfolded protein GO:0007165 signal transduction GO:0030968 endoplasmic reticulum unfolded protein response GO:0036500 ATF6-mediated unfolded protein response GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:1903892 negative regulation of ATF6-mediated unfolded protein response GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
US Server
