Human Gene SLC29A4 (uc011jwg.1)
  Description: Homo sapiens solute carrier family 29 (nucleoside transporters), member 4 (SLC29A4), transcript variant 1, mRNA.
RefSeq Summary (NM_001040661): This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Transcript (Including UTRs)
   Position: hg19 chr7:5,322,561-5,338,757 Size: 16,197 Total Exon Count: 8 Strand: +


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:5,322,561-5,338,757)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGeneNetworkH-INVHGNCLynxMalacards
PubMedTreefamWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SLC29A4
CDC HuGE Published Literature: SLC29A4

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC29A4
Diseases sorted by gene-association score: desmoplastic small round cell tumor (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.59 RPKM in Brain - Hypothalamus
Total median expression: 134.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AY485959 - Homo sapiens brain transport protein PMAT mRNA, complete cds.
AK092242 - Homo sapiens cDNA FLJ34923 fis, clone NT2RP7003107, weakly similar to 36 KDA NUCLEOLAR PROTEIN HNP36.
AX747426 - Sequence 951 from Patent EP1308459.
AK296278 - Homo sapiens cDNA FLJ55084 complete cds, highly similar to Homo sapiens solute carrier family 29 (nucleoside transporters), member 4, transcript variant 2, mRNA.
BC047592 - Homo sapiens solute carrier family 29 (nucleoside transporters), member 4, mRNA (cDNA clone MGC:48638 IMAGE:4816109), complete cds.
BC025325 - Homo sapiens solute carrier family 29 (nucleoside transporters), member 4, mRNA (cDNA clone MGC:39332 IMAGE:3354432), complete cds.
CU692970 - Synthetic construct Homo sapiens gateway clone IMAGE:100023054 5' read SLC29A4 mRNA.
KJ904046 - Synthetic construct Homo sapiens clone ccsbBroadEn_13440 SLC29A4 gene, encodes complete protein.
AK075422 - Homo sapiens cDNA PSEC0113 fis, clone NT2RP2006435, weakly similar to 36 KD NUCLEOLAR PROTEIN HNP36.
JD528922 - Sequence 509946 from Patent EP1572962.
JD543715 - Sequence 524739 from Patent EP1572962.
JD408568 - Sequence 389592 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK296278
UCSC ID: uc011jwg.1
RefSeq Accession: NM_001040661

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: AK296278.1
exon count: 8CDS single in 3' UTR: no RNA size: 1078
ORF size: 0CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 928.00frame shift in genome: no % Coverage: 99.91
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.