Description: Homo sapiens interleukin 6 (interferon, beta 2) (IL6), mRNA. RefSeq Summary (NM_000600): This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Transcript (Including UTRs) Position: hg19 chr7:22,766,766-22,770,157 Size: 3,392 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr7:22,766,882-22,769,405 Size: 2,524 Coding Exon Count: 4
ID:B5MC14_HUMAN DESCRIPTION: SubName: Full=Interleukin-6; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
ageing Giacconi R 2004, The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing., Experimental gerontology. 2004 Apr;39(4):621-8.
[PubMed 15050298]
appendicitis Rivera-Chavez, F. A. et al. 2004, Innate immunity genes influence the severity of acute appendicitis., Annals of surgery. 2004 Aug;240(2):269-77.
[PubMed 15273551]
Polymorphism in the IL-6 gene was associated with the severity of appendicitis, even after adjustment for duration of symptoms. The risk for developing appendiceal perforation or gangrene may be determined, in part, by variation in the IL-6 gene.
atherosclerosis, coronary lipids lipoprotein Wei, Y. S. et al. 2006, Relationship between interleukin-6 gene polymorphism and coronary heart disease and its effect on plasma lipid levels., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006 18(4) 233-6.
[PubMed 16647016]
IL-6 gene -572 C/G polymorphism is associated with CHD, and G allele is an important genetic marker. IL-6 gene polymorphism may affect CHD through elevation of plasma lipid and lipoprotein levels.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B5MC14
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006955 immune response GO:0010469 regulation of receptor activity
Cellular Component: GO:0005576 extracellular region
Descriptions from all associated GenBank mRNAs
LQ882870 - Sequence 19 from Patent WO2018160841. AK298077 - Homo sapiens cDNA FLJ52006 complete cds, moderately similar to Interleukin-6 precursor. AK301141 - Homo sapiens cDNA FLJ61423 complete cds, highly similar to Interleukin-6 precursor. A09363 - H.sapiens mRNA for interferon beta 2a. X04430 - Human IFN-beta 2a mRNA for interferon-beta-2. A09367 - Nucleotide sequence 5 from patent number EP0220574. AK298013 - Homo sapiens cDNA FLJ55231 complete cds, highly similar to Interleukin-6 precursor. M14584 - Human interleukin 6 mRNA, complete cds. M18403 - Human hybridoma growth factor (interleukin 6) mRNA, complete cds. BC015511 - Homo sapiens interleukin 6 (interferon, beta 2), mRNA (cDNA clone MGC:9215 IMAGE:3884652), complete cds. M54894 - Human interleukin 6 mRNA, complete cds. E03737 - cDNA encoding human B-cell differenciation factor. M29150 - Human interleukin 6 (B-cell stimulatory factor-2) mRNA, complete cds. E01518 - DNA encoding human B-cell differentiation factot. E01537 - DNA encoding human B-cell differentiation factor. E01616 - cDNA encoding human B cell differentiation factor. E02030 - cDNA sequence coding for BSF-2. E02202 - DNA encoding B cell differentiation factor (BSF-2). E02930 - DNA sequence coding for human BCDF. E11969 - cDNA encoding B-cell differentiation factor,BCDF. X04602 - Human mRNA for interleukin BSF-2 (B-cell differentiation factor). S56892 - interleukin-6 [human, tonsillar mononuclear cells, mRNA, 657 nt]. AB528399 - Synthetic construct DNA, clone: pF1KE1084, Homo sapiens IL6 gene for interleukin 6, without stop codon, in Flexi system. CR450296 - Homo sapiens full open reading frame cDNA clone RZPDo834C041D for gene IL6, interleukin 6 (interferon, beta 2); complete cds; without stopcodon. DQ894639 - Synthetic construct Homo sapiens clone IMAGE:100009099; FLH177151.01L; RZPDo839D08123D interleukin 6 (interferon, beta 2) (IL6) gene, encodes complete protein. BT019748 - Homo sapiens interleukin 6 (interferon, beta 2) mRNA, complete cds. BT019749 - Homo sapiens interleukin 6 (interferon, beta 2) mRNA, complete cds. DQ891463 - Synthetic construct clone IMAGE:100004093; FLH177154.01X; RZPDo839D08124D interleukin 6 (interferon, beta 2) (IL6) gene, encodes complete protein. JQ250825 - Homo sapiens interleukin 6 gene, complete cds. E02205 - DNA encoding human B-cell differentiation factor (BSF-2). X04403 - Human mRNA fragment for inducible 26 kDa protein (C-terminus) in fibroblasts. MP584520 - Sequence 19 from Patent WO2020081767.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04620 - Toll-like receptor signaling pathway hsa04621 - NOD-like receptor signaling pathway hsa04623 - Cytosolic DNA-sensing pathway hsa04630 - Jak-STAT signaling pathway hsa04640 - Hematopoietic cell lineage hsa04672 - Intestinal immune network for IgA production hsa05020 - Prion diseases hsa05142 - Chagas disease hsa05200 - Pathways in cancer hsa05332 - Graft-versus-host disease hsa05410 - Hypertrophic cardiomyopathy (HCM)
BioCarta from NCI Cancer Genome Anatomy Project h_erythPathway - Erythrocyte Differentiation Pathway h_il10Pathway - IL-10 Anti-inflammatory Signaling Pathway h_inflamPathway - Cytokines and Inflammatory Response h_LairPathway - Cells and Molecules involved in local acute inflammatory response h_cytokinePathway - Cytokine Network h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology h_il6Pathway - IL 6 signaling pathway h_LDLpathway - Low-density lipoprotein (LDL) pathway during atherogenesis h_il1rPathway - Signal transduction through IL1R h_il5Pathway - IL 5 Signaling Pathway h_il17Pathway - IL 17 Signaling Pathway h_stemPathway - Regulation of hematopoiesis by cytokines