Human Gene TAX1BP1 (uc011jzo.2)
Description: Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 1 (TAX1BP1), transcript variant 3, mRNA.
RefSeq Summary (NM_001206901): This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].
Transcript (Including UTRs)
Position: hg19 chr7:27,778,992-27,869,386 Size: 90,395 Total Exon Count: 17 Strand: +
Coding Region
Position: hg19 chr7:27,788,144-27,868,448 Size: 80,305 Coding Exon Count: 16
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TAX1BP1
CDC HuGE Published Literature: TAX1BP1
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D013749
Tetrachlorodibenzodioxin
C517041
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
C032668
1-nitropyrene
C111118
2',3,3',4',5-pentachloro-4-hydroxybiphenyl
C404910
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane
C011269
2,5-hexanedione
C023514
2,6-dinitrotoluene
C075773
4-phenylbutyric acid
D000082
Acetaminophen
D016573
Agrochemicals
more ... click here to view the complete list
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF07888 - Calcium binding and coiled-coil domain (CALCOCO1) like
ModBase Predicted Comparative 3D Structure on Q86VP1-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AK299729 - Homo sapiens cDNA FLJ56149 complete cds, highly similar to Tax1-binding protein 1.LF384111 - JP 2014500723-A/191614: Polycomb-Associated Non-Coding RNAs.AK314292 - Homo sapiens cDNA, FLJ95049, Homo sapiens Tax1 (human T-cell leukemia virus type I) bindingprotein 1 (TAX1BP1), mRNA.AK296720 - Homo sapiens cDNA FLJ52320 complete cds, highly similar to Tax1-binding protein 1.BC024600 - Homo sapiens cDNA clone IMAGE:4339438, containing frame-shift errors.AK301064 - Homo sapiens cDNA FLJ54388 complete cds, highly similar to Tax1-binding protein 1.AF090891 - Homo sapiens clone HQ0105 PRO0105 mRNA, complete cds.LP895568 - Sequence 432 from Patent EP3253886.AK000098 - Homo sapiens cDNA FLJ20091 fis, clone COL04152, highly similar to U33821 Human tax1-binding protein TXBP151 mRNA.AL136586 - Homo sapiens mRNA; cDNA DKFZp761B192 (from clone DKFZp761B192).BC001764 - Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 1, mRNA (cDNA clone IMAGE:3352710), **** WARNING: chimeric clone ****.U33821 - Homo sapiens tax1-binding protein TXBP151 mRNA, complete cds.BC050358 - Homo sapiens Tax1 (human T-cell leukemia virus type I) binding protein 1, mRNA (cDNA clone MGC:51743 IMAGE:6055189), complete cds.MA619688 - JP 2018138019-A/191614: Polycomb-Associated Non-Coding RNAs.AM393835 - Synthetic construct Homo sapiens clone IMAGE:100001732 for hypothetical protein (TAX1BP1 gene).CU690646 - Synthetic construct Homo sapiens gateway clone IMAGE:100021541 5' read TAX1BP1 mRNA.CR457056 - Homo sapiens full open reading frame cDNA clone RZPDo834F0514D for gene TAX1BP1, Tax1 (human T-cell leukemia virus type I) binding protein 1; complete cds, incl. stopcodon.AB463302 - Synthetic construct DNA, clone: pF1KB8592, Homo sapiens TAX1BP1 gene for Tax binding protein 1, without stop codon, in Flexi system.KJ897931 - Synthetic construct Homo sapiens clone ccsbBroadEn_07325 TAX1BP1 gene, encodes complete protein.AF268075 - Homo sapiens TRAF6-binding protein T6BP mRNA, complete cds.CR533556 - Homo sapiens full open reading frame cDNA clone RZPDo834F0621D for gene TAX1BP1, Tax1 (human T-cell leukemia virus type I) binding protein 1; complete cds, incl. stopcodon.LF362446 - JP 2014500723-A/169949: Polycomb-Associated Non-Coding RNAs.LF362449 - JP 2014500723-A/169952: Polycomb-Associated Non-Coding RNAs.LF362451 - JP 2014500723-A/169954: Polycomb-Associated Non-Coding RNAs.LF362452 - JP 2014500723-A/169955: Polycomb-Associated Non-Coding RNAs.LF362455 - JP 2014500723-A/169958: Polycomb-Associated Non-Coding RNAs.AK309757 - Homo sapiens cDNA, FLJ99798.LF362456 - JP 2014500723-A/169959: Polycomb-Associated Non-Coding RNAs.LF362457 - JP 2014500723-A/169960: Polycomb-Associated Non-Coding RNAs.LF362459 - JP 2014500723-A/169962: Polycomb-Associated Non-Coding RNAs.LF362462 - JP 2014500723-A/169965: Polycomb-Associated Non-Coding RNAs.JD026581 - Sequence 7605 from Patent EP1572962.JD028658 - Sequence 9682 from Patent EP1572962.LF362463 - JP 2014500723-A/169966: Polycomb-Associated Non-Coding RNAs.JD056033 - Sequence 37057 from Patent EP1572962.JD166409 - Sequence 147433 from Patent EP1572962.JD563286 - Sequence 544310 from Patent EP1572962.LF362464 - JP 2014500723-A/169967: Polycomb-Associated Non-Coding RNAs.LF362465 - JP 2014500723-A/169968: Polycomb-Associated Non-Coding RNAs.MA598023 - JP 2018138019-A/169949: Polycomb-Associated Non-Coding RNAs.MA598026 - JP 2018138019-A/169952: Polycomb-Associated Non-Coding RNAs.MA598028 - JP 2018138019-A/169954: Polycomb-Associated Non-Coding RNAs.MA598029 - JP 2018138019-A/169955: Polycomb-Associated Non-Coding RNAs.MA598032 - JP 2018138019-A/169958: Polycomb-Associated Non-Coding RNAs.MA598033 - JP 2018138019-A/169959: Polycomb-Associated Non-Coding RNAs.MA598034 - JP 2018138019-A/169960: Polycomb-Associated Non-Coding RNAs.MA598036 - JP 2018138019-A/169962: Polycomb-Associated Non-Coding RNAs.MA598039 - JP 2018138019-A/169965: Polycomb-Associated Non-Coding RNAs.MA598040 - JP 2018138019-A/169966: Polycomb-Associated Non-Coding RNAs.MA598041 - JP 2018138019-A/169967: Polycomb-Associated Non-Coding RNAs.MA598042 - JP 2018138019-A/169968: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: NM_001206901, NP_001193831, PRO0105, Q86VP1-2, T6BPUCSC ID: uc011jzo.2RefSeq Accession: NM_001206901
Protein: Q86VP1-2 , splice isoform of Q86VP1
CCDS: CCDS43561.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001206901.1
exon count:
17 CDS single in 3' UTR:
no
RNA size:
3383
ORF size:
2244 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
4555.50 frame shift in genome:
no
% Coverage:
99.53
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.