Human Gene ZCWPW1 (uc011kjq.2)
  Description: Homo sapiens zinc finger, CW type with PWWP domain 1 (ZCWPW1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:99,998,495-100,014,806 Size: 16,312 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr7:99,998,637-100,014,804 Size: 16,168 Coding Exon Count: 13 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:99,998,495-100,014,806)mRNA (may differ from genome)Protein (528 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIOMIMPubMed
TreefamUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.79 RPKM in Testis
Total median expression: 206.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -40.60142-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000313 - PWWP
IPR011124 - Znf_CW

Pfam Domains:
PF00855 - PWWP domain
PF07496 - CW-type Zinc Finger

SCOP Domains:
63748 - Tudor/PWWP/MBT

ModBase Predicted Comparative 3D Structure on B4DXS7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008270 zinc ion binding
GO:0046872 metal ion binding


-  Descriptions from all associated GenBank mRNAs
  BC002725 - Homo sapiens zinc finger, CW type with PWWP domain 1, mRNA (cDNA clone MGC:3436 IMAGE:3631266), complete cds.
AL136735 - Homo sapiens mRNA; cDNA DKFZp434N0510 (from clone DKFZp434N0510).
AK000919 - Homo sapiens cDNA FLJ10057 fis, clone HEMBA1001388.
AK093038 - Homo sapiens cDNA FLJ35719 fis, clone TESTI2000683.
AX747875 - Sequence 1400 from Patent EP1308459.
AK302108 - Homo sapiens cDNA FLJ57660 complete cds, highly similar to Homo sapiens zinc finger, CW type with PWWP domain 1 (ZCWPW1), mRNA.
AK300745 - Homo sapiens cDNA FLJ60897 complete cds, highly similar to Zinc finger CW-type PWWP domain protein 1.
KJ902754 - Synthetic construct Homo sapiens clone ccsbBroadEn_12148 ZCWPW1 gene, encodes complete protein.
KU178677 - Homo sapiens zinc finger CW type with PWWP domain 1 isoform 1 (ZCWPW1) mRNA, partial cds, alternatively spliced.
KU178678 - Homo sapiens zinc finger CW type with PWWP domain 1 isoform 2 (ZCWPW1) mRNA, partial cds, alternatively spliced.
KU178679 - Homo sapiens zinc finger CW type with PWWP domain 1 isoform 3 (ZCWPW1) mRNA, partial cds, alternatively spliced.
KU178680 - Homo sapiens zinc finger CW type with PWWP domain 1 isoform 4 (ZCWPW1) mRNA, complete cds, alternatively spliced.
KU178681 - Homo sapiens zinc finger CW type with PWWP domain 1 isoform 5 (ZCWPW1) mRNA, complete cds, alternatively spliced.
KU178682 - Homo sapiens zinc finger CW type with PWWP domain 1 isoform 6 (ZCWPW1) mRNA, complete cds, alternatively spliced.
CU678150 - Synthetic construct Homo sapiens gateway clone IMAGE:100019584 5' read ZCWPW1 mRNA.
JD484869 - Sequence 465893 from Patent EP1572962.
JD544110 - Sequence 525134 from Patent EP1572962.
JD519576 - Sequence 500600 from Patent EP1572962.
JD464731 - Sequence 445755 from Patent EP1572962.
JD345750 - Sequence 326774 from Patent EP1572962.
JD138719 - Sequence 119743 from Patent EP1572962.
JD065192 - Sequence 46216 from Patent EP1572962.
JD090956 - Sequence 71980 from Patent EP1572962.
JD333509 - Sequence 314533 from Patent EP1572962.
JD203498 - Sequence 184522 from Patent EP1572962.
JD392434 - Sequence 373458 from Patent EP1572962.
JD214381 - Sequence 195405 from Patent EP1572962.
JD477337 - Sequence 458361 from Patent EP1572962.
JD064763 - Sequence 45787 from Patent EP1572962.
JD469951 - Sequence 450975 from Patent EP1572962.
JD201812 - Sequence 182836 from Patent EP1572962.
JD213934 - Sequence 194958 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK302108, B4DXS7, B4DXS7_HUMAN, NM_017984, NP_060454
UCSC ID: uc011kjq.2
RefSeq Accession: NM_017984
Protein: B4DXS7

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK302108.1
exon count: 13CDS single in 3' UTR: no RNA size: 2202
ORF size: 1587CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3293.00frame shift in genome: no % Coverage: 77.25
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.