Description: Homo sapiens carboxypeptidase A4 (CPA4), transcript variant 1, mRNA. RefSeq Summary (NM_016352): This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr7:129,932,974-129,964,020 Size: 31,047 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr7:129,940,683-129,962,516 Size: 21,834 Coding Exon Count: 8
ID:CBPA4_HUMAN DESCRIPTION: RecName: Full=Carboxypeptidase A4; EC=3.4.17.-; AltName: Full=Carboxypeptidase A3; Flags: Precursor; FUNCTION: Metalloprotease that could be involved in the histone hyperacetylation pathway. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Interacts with LXN. SUBCELLULAR LOCATION: Secreted (By similarity). TISSUE SPECIFICITY: Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele. INDUCTION: Up-regulated by inhibitors of histone dacetylation. SIMILARITY: Belongs to the peptidase M14 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UI42
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
