Description: Homo sapiens muskelin 1, intracellular mediator containing kelch motifs (MKLN1), transcript variant 2, mRNA. RefSeq Summary (NM_013255): Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr7:131,012,595-131,181,398 Size: 168,804 Total Exon Count: 18 Strand: + Coding Region Position: hg19 chr7:131,012,659-131,172,487 Size: 159,829 Coding Exon Count: 18
ID:MKLN1_HUMAN DESCRIPTION: RecName: Full=Muskelin; FUNCTION: Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity). SUBUNIT: Interacts with the C-terminal tail of the prostaglandin EP3 receptor alpha isoform (By similarity). Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8. SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: Contains 1 CTLH domain. SIMILARITY: Contains 6 Kelch repeats. SIMILARITY: Contains 1 LisH domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UL63
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.