Human Gene NCAPG2 (uc011kwe.1)
  Description: Homo sapiens non-SMC condensin II complex, subunit G2 (NCAPG2), mRNA.
RefSeq Summary (NM_017760): This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Transcript (Including UTRs)
   Position: hg19 chr7:158,432,488-158,497,520 Size: 65,033 Total Exon Count: 28 Strand: -
Coding Region
   Position: hg19 chr7:158,434,156-158,494,590 Size: 60,435 Coding Exon Count: 27 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:158,432,488-158,497,520)mRNA (may differ from genome)Protein (1156 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.86 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 89.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.90145-0.399 Picture PostScript Text
3' UTR -362.911668-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF12422 - Condensin II non structural maintenance of chromosomes subunit

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain

ModBase Predicted Comparative 3D Structure on Q86XI2-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene Details   Gene Details 
Gene Sorter   Gene Sorter 
    WormBase 
    Protein Sequence 
    Alignment 

-  Descriptions from all associated GenBank mRNAs
  BC028618 - Homo sapiens non-SMC condensin II complex, subunit G2, mRNA (cDNA clone IMAGE:4821510), with apparent retained intron.
BC020560 - Homo sapiens non-SMC condensin II complex, subunit G2, mRNA (cDNA clone MGC:21468 IMAGE:3458938), complete cds.
BC043404 - Homo sapiens non-SMC condensin II complex, subunit G2, mRNA (cDNA clone MGC:50909 IMAGE:6045248), complete cds.
AK023347 - Homo sapiens cDNA FLJ13285 fis, clone OVARC1001129.
AK092008 - Homo sapiens cDNA FLJ34689 fis, clone MESAN2000815, highly similar to Homo sapiens leucine zipper protein 5 (LUZP5), mRNA.
AX747307 - Sequence 832 from Patent EP1308459.
AK000318 - Homo sapiens cDNA FLJ20311 fis, clone HEP07319.
AK022744 - Homo sapiens cDNA FLJ12682 fis, clone NT2RM4002452.
AK315699 - Homo sapiens cDNA, FLJ96798.
EU832468 - Synthetic construct Homo sapiens clone HAIB:100067497; DKFZo008C0529 non-SMC condensin II complex, subunit G2 protein (NCAPG2) gene, encodes complete protein.
EU832548 - Synthetic construct Homo sapiens clone HAIB:100067577; DKFZo004C0530 non-SMC condensin II complex, subunit G2 protein (NCAPG2) gene, encodes complete protein.
BX537845 - Homo sapiens mRNA; cDNA DKFZp686G2253 (from clone DKFZp686G2253); complete cds.
AK301901 - Homo sapiens cDNA FLJ59780 complete cds, highly similar to Homo sapiens leucine zipper protein 5 (LUZP5), mRNA.
BC005878 - Homo sapiens non-SMC condensin II complex, subunit G2, mRNA (cDNA clone IMAGE:3143004), partial cds.
JD064046 - Sequence 45070 from Patent EP1572962.
JD064047 - Sequence 45071 from Patent EP1572962.
JD441179 - Sequence 422203 from Patent EP1572962.
JD524918 - Sequence 505942 from Patent EP1572962.
JD352642 - Sequence 333666 from Patent EP1572962.
AK295057 - Homo sapiens cDNA FLJ54675 complete cds, highly similar to Homo sapiens leucine zipper protein 5 (LUZP5), mRNA.
JD025079 - Sequence 6103 from Patent EP1572962.
JD030032 - Sequence 11056 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86XI2 (Reactome details) participates in the following event(s):

R-HSA-2172666 RB1 binds condensin II
R-HSA-2288097 Condensin II complex binds H4K20me1-containing nucleosomes
R-HSA-2429719 MCPH1 sequesters condensin II
R-HSA-2294600 CDK1 phosphorylates condensin II subunit NCAPD3
R-HSA-2294580 PLK1 hyperphosphorylates Condensin II complex
R-HSA-2294590 PLK1 binds phosphorylated condensin II complex
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-68875 Mitotic Prophase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: BX537845, LUZP5, NM_017760, NP_060230, Q86XI2-2
UCSC ID: uc011kwe.1
RefSeq Accession: NM_017760
Protein: Q86XI2-2, splice isoform of Q86XI2 CCDS: CCDS64816.1, CCDS43686.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BX537845.1
exon count: 28CDS single in 3' UTR: no RNA size: 5324
ORF size: 3471CDS single in intron: no Alignment % ID: 99.89
txCdsPredict score: 7103.50frame shift in genome: no % Coverage: 98.65
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.