Description: Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C), mRNA. RefSeq Summary (NM_003841): The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: This CCDS representation uses a downstream AUG start codon. This start codon has a strong Kozak signal and is restricted to human. An upstream start codon, which has a weak Kozak signal and is conserved in some other primates, is also present. The use of the upstream start codon would result in a protein that is 40 aa longer at the N-terminus. However, this would eliminate a signal peptide that is predicted for the shorter but not the longer N-terminus. PMID:9242611 shows experimental evidence for cleavage of a signal peptide following aa 25 from the downstream start, and this is also confirmed in PMID:15340161. Therefore, the downstream start codon is represented for this CCDS. Transcript (Including UTRs) Position: hg19 chr8:22,960,327-22,974,950 Size: 14,624 Total Exon Count: 4 Strand: +
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC021569 - Homo sapiens hypothetical protein MGC31957, mRNA (cDNA clone MGC:31957 IMAGE:3959651), complete cds. BC005043 - Homo sapiens hypothetical protein MGC31957, mRNA (cDNA clone MGC:12787 IMAGE:4039959), complete cds. BC017852 - Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain, mRNA (cDNA clone IMAGE:4700855), partial cds. AK298664 - Homo sapiens cDNA FLJ52013 complete cds, highly similar to Tumor necrosis factor receptor superfamily member 10C precursor. AK313213 - Homo sapiens cDNA, FLJ93714, highly similar to Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C), mRNA. AK298718 - Homo sapiens cDNA FLJ53081 complete cds, highly similar to Tumor necrosis factor receptor superfamily member 10C precursor. AY358281 - Homo sapiens clone DNA33085 DcR1-TNFR (UNQ321) mRNA, complete cds. AF012536 - Homo sapiens decoy receptor 1 (DcR1) mRNA, complete cds. AF016267 - Homo sapiens TRAIL receptor 3 mRNA, complete cds. AF033854 - Homo sapiens lymphocyte inhibitor of TRAIL (LIT) mRNA, complete cds. AF014794 - Homo sapiens TNF related TRAIL receptor (TNFRSF10C) mRNA, complete cds. BC125041 - Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain, mRNA (cDNA clone MGC:149501 IMAGE:40115748), complete cds. BC125042 - Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain, mRNA (cDNA clone MGC:149502 IMAGE:40115749), complete cds. JF432560 - Synthetic construct Homo sapiens clone IMAGE:100073790 hypothetical protein MGC31957 (MGC31957) gene, encodes complete protein. KJ904068 - Synthetic construct Homo sapiens clone ccsbBroadEn_13462 LOC254896 gene, encodes complete protein. AF020502 - Homo sapiens cytotoxic TRAIL receptor-3 (TRAIL-R3) mRNA, complete cds. JD127924 - Sequence 108948 from Patent EP1572962. KJ892621 - Synthetic construct Homo sapiens clone ccsbBroadEn_02015 TNFRSF10C gene, encodes complete protein. AF012629 - Homo sapiens antagonist decoy receptor for TRAIL/Apo-2L (TRID) mRNA, complete cds. CR541857 - Homo sapiens full open reading frame cDNA clone RZPDo834G0632D for gene TNFRSF10C, tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; complete cds, incl. stopcodon. JD462083 - Sequence 443107 from Patent EP1572962. JD157671 - Sequence 138695 from Patent EP1572962. JD259529 - Sequence 240553 from Patent EP1572962. JD398068 - Sequence 379092 from Patent EP1572962. JD519535 - Sequence 500559 from Patent EP1572962. JD549207 - Sequence 530231 from Patent EP1572962. JD190535 - Sequence 171559 from Patent EP1572962. JD123108 - Sequence 104132 from Patent EP1572962. JD228373 - Sequence 209397 from Patent EP1572962. JD159809 - Sequence 140833 from Patent EP1572962. JD249005 - Sequence 230029 from Patent EP1572962. JD521203 - Sequence 502227 from Patent EP1572962. JD095741 - Sequence 76765 from Patent EP1572962. JD408287 - Sequence 389311 from Patent EP1572962.