Human Gene TACC1 (uc011lcd.2)
  Description: Homo sapiens transforming, acidic coiled-coil containing protein 1 (TACC1), transcript variant 3, mRNA.
RefSeq Summary (NM_001146216): This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017].
Transcript (Including UTRs)
   Position: hg19 chr8:38,677,040-38,710,546 Size: 33,507 Total Exon Count: 10 Strand: +


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:38,677,040-38,710,546)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerH-INVHGNCLynxMalacards
PubMedTreefamWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TACC1
CDC HuGE Published Literature: TACC1

-  MalaCards Disease Associations
  MalaCards Gene Search: TACC1
Diseases sorted by gene-association score: gliosarcoma* (202), giant cell glioblastoma* (132), breast cancer (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 57.86 RPKM in Esophagus - Muscularis
Total median expression: 1170.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BX647696 - Homo sapiens mRNA; cDNA DKFZp686K18126 (from clone DKFZp686K18126).
AY072873 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-B (TACC1) mRNA, partial cds; alternatively spliced.
AY072876 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-E (TACC1) mRNA, partial cds; alternatively spliced.
AK304774 - Homo sapiens cDNA FLJ52058 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK295071 - Homo sapiens cDNA FLJ50409 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK303596 - Homo sapiens cDNA FLJ52382 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK304507 - Homo sapiens cDNA FLJ56209 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
BC041391 - Homo sapiens transforming, acidic coiled-coil containing protein 1, mRNA (cDNA clone MGC:43967 IMAGE:5276767), complete cds.
JF432777 - Synthetic construct Homo sapiens clone IMAGE:100074021 transforming, acidic coiled-coil containing protein 1 (TACC1) gene, encodes complete protein.
KJ901774 - Synthetic construct Homo sapiens clone ccsbBroadEn_11168 TACC1 gene, encodes complete protein.
AY072874 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-C (TACC1) mRNA, partial cds; alternatively spliced.
AY072875 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-D (TACC1) mRNA, partial cds; alternatively spliced.
AK308849 - Homo sapiens cDNA, FLJ98890.
AK314620 - Homo sapiens cDNA, FLJ95461, highly similar to Homo sapiens transforming, acidic coiled-coil containing protein 1 (TACC1), mRNA.
AF049910 - Homo sapiens TACC1 (TACC1) mRNA, complete cds.
AY177411 - Homo sapiens transforming acidic coiled-coil containing protein 1 short isoform (TACC1) mRNA, complete cds.
AB463317 - Synthetic construct DNA, clone: pF1KB9572, Homo sapiens TACC1 gene for transforming, acidic coiled-coil containing protein 1, without stop codon, in Flexi system.
AK294931 - Homo sapiens cDNA FLJ50512 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK295841 - Homo sapiens cDNA FLJ50411 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AB029026 - Homo sapiens mRNA for KIAA1103 protein, partial cds.
AK304725 - Homo sapiens cDNA FLJ52297 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AY039239 - Homo sapiens gastric cancer antigen Ga55 (TACC1) mRNA, partial cds.
AY139007 - Homo sapiens TACC1-like protein mRNA, complete cds.
AK098223 - Homo sapiens cDNA FLJ40904 fis, clone UTERU2004564.
JD269219 - Sequence 250243 from Patent EP1572962.
JD518997 - Sequence 500021 from Patent EP1572962.
JD232862 - Sequence 213886 from Patent EP1572962.
JD460356 - Sequence 441380 from Patent EP1572962.
JD562431 - Sequence 543455 from Patent EP1572962.
JD090700 - Sequence 71724 from Patent EP1572962.
JD432693 - Sequence 413717 from Patent EP1572962.
JD097217 - Sequence 78241 from Patent EP1572962.
JD366946 - Sequence 347970 from Patent EP1572962.
JD488925 - Sequence 469949 from Patent EP1572962.
JD215340 - Sequence 196364 from Patent EP1572962.
JD066446 - Sequence 47470 from Patent EP1572962.
JD299305 - Sequence 280329 from Patent EP1572962.
JD111988 - Sequence 93012 from Patent EP1572962.
JD498058 - Sequence 479082 from Patent EP1572962.
JD564664 - Sequence 545688 from Patent EP1572962.
JD416178 - Sequence 397202 from Patent EP1572962.
JD082630 - Sequence 63654 from Patent EP1572962.
JD061437 - Sequence 42461 from Patent EP1572962.
JD451221 - Sequence 432245 from Patent EP1572962.
JD376142 - Sequence 357166 from Patent EP1572962.
JD376143 - Sequence 357167 from Patent EP1572962.
JD498039 - Sequence 479063 from Patent EP1572962.
JD276461 - Sequence 257485 from Patent EP1572962.
JD553521 - Sequence 534545 from Patent EP1572962.
JD431286 - Sequence 412310 from Patent EP1572962.
JD564036 - Sequence 545060 from Patent EP1572962.
JD557159 - Sequence 538183 from Patent EP1572962.
JD088620 - Sequence 69644 from Patent EP1572962.
JD267398 - Sequence 248422 from Patent EP1572962.
JD447678 - Sequence 428702 from Patent EP1572962.
JD085109 - Sequence 66133 from Patent EP1572962.
JD249564 - Sequence 230588 from Patent EP1572962.
JD378010 - Sequence 359034 from Patent EP1572962.
JD354049 - Sequence 335073 from Patent EP1572962.
JD269657 - Sequence 250681 from Patent EP1572962.
JD189797 - Sequence 170821 from Patent EP1572962.
JD251491 - Sequence 232515 from Patent EP1572962.
JD036424 - Sequence 17448 from Patent EP1572962.
JD036748 - Sequence 17772 from Patent EP1572962.
JD433674 - Sequence 414698 from Patent EP1572962.
JD234837 - Sequence 215861 from Patent EP1572962.
JD483720 - Sequence 464744 from Patent EP1572962.
JD048828 - Sequence 29852 from Patent EP1572962.
JD369324 - Sequence 350348 from Patent EP1572962.
JD300223 - Sequence 281247 from Patent EP1572962.
JD314705 - Sequence 295729 from Patent EP1572962.
DQ601424 - Homo sapiens piRNA piR-39490, complete sequence.
JD170964 - Sequence 151988 from Patent EP1572962.
JD554021 - Sequence 535045 from Patent EP1572962.
JD516773 - Sequence 497797 from Patent EP1572962.
JD313559 - Sequence 294583 from Patent EP1572962.
JD343373 - Sequence 324397 from Patent EP1572962.
JD378971 - Sequence 359995 from Patent EP1572962.
JD389673 - Sequence 370697 from Patent EP1572962.
JD292900 - Sequence 273924 from Patent EP1572962.
JD061641 - Sequence 42665 from Patent EP1572962.
JD466145 - Sequence 447169 from Patent EP1572962.
JD281080 - Sequence 262104 from Patent EP1572962.
JD209510 - Sequence 190534 from Patent EP1572962.
JD333433 - Sequence 314457 from Patent EP1572962.
JD182987 - Sequence 164011 from Patent EP1572962.
JD093916 - Sequence 74940 from Patent EP1572962.
AF075051 - Homo sapiens full length insert cDNA YN99C01.
JD355069 - Sequence 336093 from Patent EP1572962.
JD552697 - Sequence 533721 from Patent EP1572962.
JD363699 - Sequence 344723 from Patent EP1572962.
JD368311 - Sequence 349335 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK304725
UCSC ID: uc011lcd.2
RefSeq Accession: NM_001146216

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: AK304725.1
exon count: 10CDS single in 3' UTR: no RNA size: 1549
ORF size: 0CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 1322.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.