Description: Homo sapiens heterogeneous nuclear ribonucleoprotein K (HNRNPK), transcript variant 2, mRNA. RefSeq Summary (NM_031263): This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr9:86,582,998-86,590,713 Size: 7,716 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr9:86,584,322-86,587,029 Size: 2,708 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 54791 - Eukaryotic type KH-domain (KH-domain type I) 54814 - Prokaryotic type KH domain (KH-domain type II)
ModBase Predicted Comparative 3D Structure on P61978-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
X72727 - H.sapiens tunp mRNA for transformation upregulated nuclear protein. AB209562 - Homo sapiens mRNA for heterogeneous nuclear ribonucleoprotein K isoform a variant protein. BC013220 - Homo sapiens heterogeneous nuclear ribonucleoprotein K, mRNA (cDNA clone IMAGE:4149675). AK096385 - Homo sapiens cDNA FLJ39066 fis, clone NT2RP7014743, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K. S74678 - heterogeneous nuclear ribonucleoprotein complex K [human, mRNA, 2302 nt]. JD548770 - Sequence 529794 from Patent EP1572962. JD262561 - Sequence 243585 from Patent EP1572962. BC063540 - Homo sapiens cDNA clone IMAGE:4523373, **** WARNING: chimeric clone ****. BC000355 - Homo sapiens heterogeneous nuclear ribonucleoprotein K, mRNA (cDNA clone MGC:8660 IMAGE:2964383), complete cds. BC025321 - Homo sapiens heterogeneous nuclear ribonucleoprotein K, mRNA (cDNA clone IMAGE:5421682). BC014980 - Homo sapiens heterogeneous nuclear ribonucleoprotein K, mRNA (cDNA clone MGC:23171 IMAGE:4906241), complete cds. AK123117 - Homo sapiens cDNA FLJ41122 fis, clone BRACE2013911, highly similar to HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K. AK300744 - Homo sapiens cDNA FLJ54552 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein K. JD469161 - Sequence 450185 from Patent EP1572962. AY911506 - Homo sapiens heterogeneous nuclear ribonucleoprotein K transcript variant (HNRPK) mRNA, complete cds, alternatively spliced. AK294067 - Homo sapiens cDNA FLJ53312 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein K. JD036591 - Sequence 17615 from Patent EP1572962. AK291336 - Homo sapiens cDNA FLJ77137 complete cds, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein K (HNRPK), transcript variant 1, mRNA. KJ896997 - Synthetic construct Homo sapiens clone ccsbBroadEn_06391 HNRNPK gene, encodes complete protein. AB451263 - Homo sapiens HNRNPK mRNA for heterogeneous nuclear ribonucleoprotein K isoform a, complete cds, clone: FLJ08080AAAN. CR456771 - Homo sapiens full open reading frame cDNA clone RZPDo834E024D for gene HNRPK, heterogeneous nuclear ribonucleoprotein K; complete cds, incl. stopcodon. DQ890727 - Synthetic construct clone IMAGE:100003357; FLH165506.01X; RZPDo839D03160D heterogeneous nuclear ribonucleoprotein K (HNRPK) gene, encodes complete protein. KJ891374 - Synthetic construct Homo sapiens clone ccsbBroadEn_00768 HNRNPK gene, encodes complete protein. DQ893902 - Synthetic construct Homo sapiens clone IMAGE:100008362; FLH165502.01L; RZPDo839D03159D heterogeneous nuclear ribonucleoprotein K (HNRPK) gene, encodes complete protein. AB384978 - Synthetic construct DNA, clone: pF1KB4689, Homo sapiens HNRPK gene for heterogeneous nuclear ribonucleoprotein K, complete cds, without stop codon, in Flexi system. AB451390 - Homo sapiens HNRNPK mRNA for heterogeneous nuclear ribonucleoprotein K isoform a, partial cds, clone: FLJ08080AAAF. AK307962 - Homo sapiens cDNA, FLJ97910. CU674174 - Synthetic construct Homo sapiens gateway clone IMAGE:100018317 5' read HNRPK mRNA. JD534300 - Sequence 515324 from Patent EP1572962. JD525400 - Sequence 506424 from Patent EP1572962. JD364953 - Sequence 345977 from Patent EP1572962. JD342559 - Sequence 323583 from Patent EP1572962. JD173827 - Sequence 154851 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03040 - Spliceosome
Reactome (by CSHL, EBI, and GO)
Protein P61978 (Reactome details) participates in the following event(s):
R-HSA-72103 Formation of pre-mRNPs R-HSA-4570499 CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-8953854 Metabolism of RNA R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins R-HSA-72172 mRNA Splicing R-HSA-2990846 SUMOylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins