Description: Homo sapiens SECIS binding protein 2 (SECISBP2), mRNA. RefSeq Summary (NM_024077): The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]. Transcript (Including UTRs) Position: hg19 chr9:91,933,412-91,974,561 Size: 41,150 Total Exon Count: 17 Strand: + Coding Region Position: hg19 chr9:91,933,492-91,973,739 Size: 40,248 Coding Exon Count: 17
ID:SEBP2_HUMAN DESCRIPTION: RecName: Full=Selenocysteine insertion sequence-binding protein 2; Short=SECIS-binding protein 2; FUNCTION: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB. SUBUNIT: Interacts with SELB (By similarity). SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Expressed at high levels in testis. DISEASE: Defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]. This phenotype is associated with a reduction in type II iodothyronine deiodinase activity.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96T21
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK302852 - Homo sapiens cDNA FLJ54472 complete cds, highly similar to SECIS-binding protein 2. KX533480 - Homo sapiens selenocysteine insertion sequence-binding protein 2 (SECISBP2) mRNA, complete cds. AK090608 - Homo sapiens cDNA FLJ33289 fis, clone BGGI12001075, moderately similar to Rattus norvegicus mRNA for SECIS binding protein 2 (sbp2 gene). AX746532 - Sequence 57 from Patent EP1308459. AK290182 - Homo sapiens cDNA FLJ75613 complete cds. BC036109 - Homo sapiens SECIS binding protein 2, mRNA (cDNA clone MGC:33935 IMAGE:5296292), complete cds. AB208940 - Homo sapiens premature mRNA for hypothetical protein DKFZp434B216 variant. BC001189 - Homo sapiens SECIS binding protein 2, mRNA (cDNA clone IMAGE:3354449), complete cds. AL136881 - Homo sapiens mRNA; cDNA DKFZp434B216 (from clone DKFZp434B216). AF380995 - Homo sapiens SECIS binding protein 2 (SBP2) mRNA, complete cds. BC099900 - Homo sapiens SECIS binding protein 2, mRNA (cDNA clone IMAGE:6146359), partial cds. BC068466 - Homo sapiens SECIS binding protein 2, mRNA (cDNA clone IMAGE:5297396). KJ903142 - Synthetic construct Homo sapiens clone ccsbBroadEn_12536 SECISBP2 gene, encodes complete protein. AK299161 - Homo sapiens cDNA FLJ61343 complete cds, highly similar to SECIS-binding protein 2. AB463244 - Synthetic construct DNA, clone: pF1KB8574, Homo sapiens SECISBP2 gene for SECIS binding protein 2, without stop codon, in Flexi system. AM392812 - Synthetic construct Homo sapiens clone IMAGE:100001851 for hypothetical protein (SECISBP2 gene). AM393701 - Synthetic construct Homo sapiens clone IMAGE:100002025 for hypothetical protein (SECISBP2 gene). BX648787 - Homo sapiens mRNA; cDNA DKFZp686C09169 (from clone DKFZp686C09169). BC023142 - Homo sapiens SECIS binding protein 2, mRNA (cDNA clone IMAGE:3917564), partial cds. AK023078 - Homo sapiens cDNA FLJ13016 fis, clone NT2RP3000624, moderately similar to Rattus norvegicus mRNA for SECIS binding protein 2 (sbp2 gene). BC038854 - Homo sapiens SECIS binding protein 2, mRNA (cDNA clone IMAGE:5209694), **** WARNING: chimeric clone ****. JD315710 - Sequence 296734 from Patent EP1572962. JD087604 - Sequence 68628 from Patent EP1572962. JD109300 - Sequence 90324 from Patent EP1572962. JD344457 - Sequence 325481 from Patent EP1572962. JD448760 - Sequence 429784 from Patent EP1572962. JD028179 - Sequence 9203 from Patent EP1572962. JD561081 - Sequence 542105 from Patent EP1572962. JD349177 - Sequence 330201 from Patent EP1572962. JD177581 - Sequence 158605 from Patent EP1572962. JD266839 - Sequence 247863 from Patent EP1572962. JD465925 - Sequence 446949 from Patent EP1572962. JD232368 - Sequence 213392 from Patent EP1572962. JD279844 - Sequence 260868 from Patent EP1572962. JD553919 - Sequence 534943 from Patent EP1572962. JD303340 - Sequence 284364 from Patent EP1572962. JD314413 - Sequence 295437 from Patent EP1572962. JD244765 - Sequence 225789 from Patent EP1572962. JD439196 - Sequence 420220 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96T21 (Reactome details) participates in the following event(s):
R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-2408557 Selenocysteine synthesis R-HSA-2408522 Selenoamino acid metabolism R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1430728 Metabolism