Human Gene TRIM14 (uc011luz.1)
  Description: Homo sapiens tripartite motif containing 14 (TRIM14), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr9:100,846,637-100,854,843 Size: 8,207 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr9:100,849,752-100,854,806 Size: 5,055 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:100,846,637-100,854,843)mRNA (may differ from genome)Protein (220 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMalacardsMGIPubMed
TreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: B4E0G2_HUMAN
DESCRIPTION: SubName: Full=cDNA FLJ55267, highly similar to Tripartite motif-containing protein 14;
SIMILARITY: Contains 1 B30.2/SPRY domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TRIM14
CDC HuGE Published Literature: TRIM14
Positive Disease Associations: Body Height
Related Studies:
  1. Body Height
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: TRIM14
Diseases sorted by gene-association score: bone cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.89 RPKM in Spleen
Total median expression: 245.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.3037-0.197 Picture PostScript Text
3' UTR -1032.453115-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt

Pfam Domains:
PF00622 - SPRY domain
PF13765 - SPRY-associated domain

ModBase Predicted Comparative 3D Structure on B4E0G2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC006333 - Homo sapiens tripartite motif-containing 14, mRNA (cDNA clone MGC:12564 IMAGE:4299815), complete cds.
LF385385 - JP 2014500723-A/192888: Polycomb-Associated Non-Coding RNAs.
AK097480 - Homo sapiens cDNA FLJ40161 fis, clone TESTI2015710.
AF220130 - Homo sapiens tripartite motif protein TRIM14 alpha (TRIM14) mRNA, complete cds; alternatively spliced.
AF220131 - Homo sapiens tripartite motif protein TRIM14 beta (TRIM14) mRNA, complete cds; alternatively spliced.
D50919 - Homo sapiens mRNA for KIAA0129 gene, complete cds.
JD047031 - Sequence 28055 from Patent EP1572962.
JD143743 - Sequence 124767 from Patent EP1572962.
JD059468 - Sequence 40492 from Patent EP1572962.
JD499165 - Sequence 480189 from Patent EP1572962.
DQ575048 - Homo sapiens piRNA piR-43160, complete sequence.
JD303610 - Sequence 284634 from Patent EP1572962.
JD149434 - Sequence 130458 from Patent EP1572962.
JD366580 - Sequence 347604 from Patent EP1572962.
JD185395 - Sequence 166419 from Patent EP1572962.
JD105980 - Sequence 87004 from Patent EP1572962.
JD517762 - Sequence 498786 from Patent EP1572962.
JD105979 - Sequence 87003 from Patent EP1572962.
JD364568 - Sequence 345592 from Patent EP1572962.
JD451517 - Sequence 432541 from Patent EP1572962.
JD534423 - Sequence 515447 from Patent EP1572962.
JD185394 - Sequence 166418 from Patent EP1572962.
JD292392 - Sequence 273416 from Patent EP1572962.
JD175460 - Sequence 156484 from Patent EP1572962.
JD472346 - Sequence 453370 from Patent EP1572962.
JD481559 - Sequence 462583 from Patent EP1572962.
JD421389 - Sequence 402413 from Patent EP1572962.
JD199404 - Sequence 180428 from Patent EP1572962.
JD301871 - Sequence 282895 from Patent EP1572962.
DQ580636 - Homo sapiens piRNA piR-48748, complete sequence.
JD467234 - Sequence 448258 from Patent EP1572962.
DQ598157 - Homo sapiens piRNA piR-36223, complete sequence.
DQ598156 - Homo sapiens piRNA piR-36222, complete sequence.
JD346309 - Sequence 327333 from Patent EP1572962.
DQ573670 - Homo sapiens piRNA piR-41782, complete sequence.
JD323701 - Sequence 304725 from Patent EP1572962.
JD431292 - Sequence 412316 from Patent EP1572962.
JD546479 - Sequence 527503 from Patent EP1572962.
JD228813 - Sequence 209837 from Patent EP1572962.
DQ592537 - Homo sapiens piRNA piR-59649, complete sequence.
DQ600591 - Homo sapiens piRNA piR-38657, complete sequence.
DQ574716 - Homo sapiens piRNA piR-42828, complete sequence.
JD527028 - Sequence 508052 from Patent EP1572962.
JD080457 - Sequence 61481 from Patent EP1572962.
JD206203 - Sequence 187227 from Patent EP1572962.
JD381142 - Sequence 362166 from Patent EP1572962.
DQ573519 - Homo sapiens piRNA piR-41631, complete sequence.
JD248993 - Sequence 230017 from Patent EP1572962.
JD037320 - Sequence 18344 from Patent EP1572962.
JD137842 - Sequence 118866 from Patent EP1572962.
JD263912 - Sequence 244936 from Patent EP1572962.
JD296246 - Sequence 277270 from Patent EP1572962.
JD236989 - Sequence 218013 from Patent EP1572962.
JD441032 - Sequence 422056 from Patent EP1572962.
JD089875 - Sequence 70899 from Patent EP1572962.
DQ592709 - Homo sapiens piRNA piR-59821, complete sequence.
JD302992 - Sequence 284016 from Patent EP1572962.
DQ596178 - Homo sapiens piRNA piR-34244, complete sequence.
DQ590364 - Homo sapiens piRNA piR-57476, complete sequence.
DQ592139 - Homo sapiens piRNA piR-59251, complete sequence.
JD323502 - Sequence 304526 from Patent EP1572962.
DQ574549 - Homo sapiens piRNA piR-42661, complete sequence.
DQ596856 - Homo sapiens piRNA piR-34922, complete sequence.
DQ599276 - Homo sapiens piRNA piR-37342, complete sequence.
JD302404 - Sequence 283428 from Patent EP1572962.
JD387317 - Sequence 368341 from Patent EP1572962.
JD462986 - Sequence 444010 from Patent EP1572962.
JD181341 - Sequence 162365 from Patent EP1572962.
JD230574 - Sequence 211598 from Patent EP1572962.
JD126974 - Sequence 107998 from Patent EP1572962.
JD200142 - Sequence 181166 from Patent EP1572962.
JD132165 - Sequence 113189 from Patent EP1572962.
DQ600931 - Homo sapiens piRNA piR-38997, complete sequence.
DQ592891 - Homo sapiens piRNA piR-60003, complete sequence.
DQ601333 - Homo sapiens piRNA piR-39399, complete sequence.
DQ597206 - Homo sapiens piRNA piR-35272, complete sequence.
DQ573141 - Homo sapiens piRNA piR-41253, complete sequence.
DQ573140 - Homo sapiens piRNA piR-41252, complete sequence.
DQ599744 - Homo sapiens piRNA piR-37810, complete sequence.
AK316464 - Homo sapiens cDNA, FLJ79363 complete cds, highly similar to Tripartite motif-containing protein 14.
AK055833 - Homo sapiens cDNA FLJ31271 fis, clone KIDNE2006149, weakly similar to Xenopus laevis RING finger protein mRNA.
JD525394 - Sequence 506418 from Patent EP1572962.
DQ583228 - Homo sapiens piRNA piR-50340, complete sequence.
JD126922 - Sequence 107946 from Patent EP1572962.
JD371517 - Sequence 352541 from Patent EP1572962.
DQ594171 - Homo sapiens piRNA piR-60283, complete sequence.
AK303366 - Homo sapiens cDNA FLJ55267 complete cds, highly similar to Tripartite motif-containing protein 14.
DQ594501 - Homo sapiens piRNA piR-60613, complete sequence.
JD430692 - Sequence 411716 from Patent EP1572962.
JD394167 - Sequence 375191 from Patent EP1572962.
JD161935 - Sequence 142959 from Patent EP1572962.
JD133954 - Sequence 114978 from Patent EP1572962.
DQ574742 - Homo sapiens piRNA piR-42854, complete sequence.
DQ597010 - Homo sapiens piRNA piR-35076, complete sequence.
DQ597009 - Homo sapiens piRNA piR-35075, complete sequence.
DQ597011 - Homo sapiens piRNA piR-35077, complete sequence.
DQ572901 - Homo sapiens piRNA piR-41013, complete sequence.
DQ597008 - Homo sapiens piRNA piR-35074, complete sequence.
JD468167 - Sequence 449191 from Patent EP1572962.
JD417267 - Sequence 398291 from Patent EP1572962.
JD435097 - Sequence 416121 from Patent EP1572962.
JD128464 - Sequence 109488 from Patent EP1572962.
JD520293 - Sequence 501317 from Patent EP1572962.
JD248129 - Sequence 229153 from Patent EP1572962.
JD392077 - Sequence 373101 from Patent EP1572962.
JD107174 - Sequence 88198 from Patent EP1572962.
AK292825 - Homo sapiens cDNA FLJ75477 complete cds, highly similar to Homo sapiens tripartite motif-containing 14 (TRIM14), transcript variant 3, mRNA.
DQ596304 - Homo sapiens piRNA piR-34370, complete sequence.
JD048057 - Sequence 29081 from Patent EP1572962.
JD224570 - Sequence 205594 from Patent EP1572962.
JD460099 - Sequence 441123 from Patent EP1572962.
DQ893293 - Synthetic construct clone IMAGE:100005923; FLH196222.01X; RZPDo839F11154D tripartite motif-containing 14 (TRIM14) gene, encodes complete protein.
DQ896623 - Synthetic construct Homo sapiens clone IMAGE:100011083; FLH196218.01L; RZPDo839F11153D tripartite motif-containing 14 (TRIM14) gene, encodes complete protein.
AB529155 - Synthetic construct DNA, clone: pF1KA0129, Homo sapiens TRIM14 gene for tripartite motif-containing protein 14, without stop codon, in Flexi system.
MA620962 - JP 2018138019-A/192888: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK303366, B4E0G2, B4E0G2_HUMAN, NM_033220, NP_150089
UCSC ID: uc011luz.1
RefSeq Accession: NM_033220
Protein: B4E0G2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK303366.1
exon count: 3CDS single in 3' UTR: no RNA size: 1200
ORF size: 663CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1474.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 3087# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.