Description: Homo sapiens cysteine conjugate-beta lyase, cytoplasmic (RP11-545E17.13), transcript variant 1, mRNA. RefSeq Summary (NM_004059): This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr9:131,595,392-131,644,354 Size: 48,963 Total Exon Count: 15 Strand: - Coding Region Position: hg19 chr9:131,595,863-131,609,807 Size: 13,945 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B7Z4W5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006575 cellular modified amino acid metabolic process GO:0009058 biosynthetic process GO:0070189 kynurenine metabolic process GO:0097052 L-kynurenine metabolic process