Description: Homo sapiens arylsulfatase family, member H (ARSH), mRNA. RefSeq Summary (NM_001011719): Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381130.3/ ENSP00000370522.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chrX:2,924,654-2,951,426 Size: 26,773 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chrX:2,924,654-2,951,426 Size: 26,773 Coding Exon Count: 9
ID:ARSH_HUMAN DESCRIPTION: RecName: Full=Arylsulfatase H; Short=ASH; EC=3.1.6.-; COFACTOR: Binds 1 calcium ion per subunit (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). PTM: The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity). SIMILARITY: Belongs to the sulfatase family.
ModBase Predicted Comparative 3D Structure on Q5FYA8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Cellular Component: GO:0005788 endoplasmic reticulum lumen GO:0016020 membrane GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
AB527111 - Synthetic construct DNA, clone: pF1KE0376, Homo sapiens ARSH gene for arylsulfatase family, member H, without stop codon, in Flexi system. BC148492 - Synthetic construct Homo sapiens clone IMAGE:100015431, MGC:183032 arylsulfatase family, member H (ARSH) mRNA, encodes complete protein. BC153085 - Synthetic construct Homo sapiens clone IMAGE:100016343, MGC:184294 arylsulfatase family, member H (ARSH) mRNA, encodes complete protein. AY875940 - Homo sapiens arylsulfatase H (ARSH) mRNA, complete cds. AX801696 - Sequence 5 from Patent WO03057869.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q5FYA8 (Reactome details) participates in the following event(s):
R-HSA-1614362 SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases R-HSA-1660662 Glycosphingolipid metabolism R-HSA-1663150 The activation of arylsulfatases R-HSA-428157 Sphingolipid metabolism R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-556833 Metabolism of lipids R-HSA-597592 Post-translational protein modification R-HSA-1430728 Metabolism R-HSA-392499 Metabolism of proteins