Human Gene ZNF275 (uc011myn.2)
  Description: Homo sapiens zinc finger protein 275 (ZNF275), mRNA.
RefSeq Summary (NM_001080485): This gene encodes a zinc finger protein that appears to be conserved in eutheria. Its function has not yet been established. [provided by RefSeq, Jul 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Transcript (Including UTRs)
   Position: hg19 chrX:152,610,234-152,617,037 Size: 6,804 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chrX:152,612,333-152,613,433 Size: 1,101 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:152,610,234-152,617,037)mRNA (may differ from genome)Protein (366 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN275_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 275;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.65 RPKM in Adrenal Gland
Total median expression: 243.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -317.82902-0.352 Picture PostScript Text
3' UTR -1161.073604-0.322 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9NSD4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK122976 - Homo sapiens cDNA FLJ16723 fis, clone UTERU3004418, highly similar to Zinc finger protein 275.
BC001545 - Homo sapiens, Similar to zinc finger protein 275, clone IMAGE:3453569, mRNA.
BC136634 - Homo sapiens zinc finger protein 275, mRNA (cDNA clone MGC:168247 IMAGE:9020624), complete cds.
AK127133 - Homo sapiens cDNA FLJ45190 fis, clone BRAWH3049271, highly similar to Zinc finger protein 275.
JD173536 - Sequence 154560 from Patent EP1572962.
JD195467 - Sequence 176491 from Patent EP1572962.
JD498820 - Sequence 479844 from Patent EP1572962.
JD486587 - Sequence 467611 from Patent EP1572962.
JD389307 - Sequence 370331 from Patent EP1572962.
JD147980 - Sequence 129004 from Patent EP1572962.
JD244401 - Sequence 225425 from Patent EP1572962.
JD323761 - Sequence 304785 from Patent EP1572962.
JD241014 - Sequence 222038 from Patent EP1572962.
JD420595 - Sequence 401619 from Patent EP1572962.
JD111050 - Sequence 92074 from Patent EP1572962.
JD084478 - Sequence 65502 from Patent EP1572962.
AL833683 - Homo sapiens mRNA; cDNA DKFZp667K1122 (from clone DKFZp667K1122).
JD058716 - Sequence 39740 from Patent EP1572962.
JD539092 - Sequence 520116 from Patent EP1572962.
JD048658 - Sequence 29682 from Patent EP1572962.
JD476491 - Sequence 457515 from Patent EP1572962.
JD507801 - Sequence 488825 from Patent EP1572962.
JD376501 - Sequence 357525 from Patent EP1572962.
JD075557 - Sequence 56581 from Patent EP1572962.
JD209680 - Sequence 190704 from Patent EP1572962.
JD110583 - Sequence 91607 from Patent EP1572962.
AK172795 - Homo sapiens cDNA FLJ23956 fis, clone HEP11903.
JD146751 - Sequence 127775 from Patent EP1572962.
JD280673 - Sequence 261697 from Patent EP1572962.
JD379001 - Sequence 360025 from Patent EP1572962.
JD315884 - Sequence 296908 from Patent EP1572962.
JD036610 - Sequence 17634 from Patent EP1572962.
JD385790 - Sequence 366814 from Patent EP1572962.
JD384675 - Sequence 365699 from Patent EP1572962.
JD498449 - Sequence 479473 from Patent EP1572962.
JD314038 - Sequence 295062 from Patent EP1572962.
JD086702 - Sequence 67726 from Patent EP1572962.
JD427509 - Sequence 408533 from Patent EP1572962.
JD507182 - Sequence 488206 from Patent EP1572962.
JD165670 - Sequence 146694 from Patent EP1572962.
JD559961 - Sequence 540985 from Patent EP1572962.
BC041602 - Homo sapiens zinc finger protein 275, mRNA (cDNA clone IMAGE:5470785), partial cds.
BC018767 - Homo sapiens zinc finger protein 275, mRNA (cDNA clone IMAGE:4637407), with apparent retained intron.
JD343501 - Sequence 324525 from Patent EP1572962.
JD180158 - Sequence 161182 from Patent EP1572962.
JD370124 - Sequence 351148 from Patent EP1572962.
JD456108 - Sequence 437132 from Patent EP1572962.
JD212064 - Sequence 193088 from Patent EP1572962.
JD149770 - Sequence 130794 from Patent EP1572962.
JD436814 - Sequence 417838 from Patent EP1572962.
JD163526 - Sequence 144550 from Patent EP1572962.
JD480283 - Sequence 461307 from Patent EP1572962.
JD323827 - Sequence 304851 from Patent EP1572962.
JD074516 - Sequence 55540 from Patent EP1572962.
JD086501 - Sequence 67525 from Patent EP1572962.
JD283022 - Sequence 264046 from Patent EP1572962.
JD256402 - Sequence 237426 from Patent EP1572962.
JD145532 - Sequence 126556 from Patent EP1572962.
JD232815 - Sequence 213839 from Patent EP1572962.
JD560474 - Sequence 541498 from Patent EP1572962.
JD051449 - Sequence 32473 from Patent EP1572962.
JD144947 - Sequence 125971 from Patent EP1572962.
JD296167 - Sequence 277191 from Patent EP1572962.
JD548471 - Sequence 529495 from Patent EP1572962.
JD494250 - Sequence 475274 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC136634, NM_001080485, NP_001073954, Q9NSD4, ZN275_HUMAN
UCSC ID: uc011myn.2
RefSeq Accession: NM_001080485
Protein: Q9NSD4 (aka ZN275_HUMAN or Z275_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC136634.1
exon count: 2CDS single in 3' UTR: no RNA size: 3852
ORF size: 1101CDS single in intron: no Alignment % ID: 99.79
txCdsPredict score: 1900.50frame shift in genome: no % Coverage: 87.28
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 4668# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.