Description: Homo sapiens centrosomal protein 170kDa (CEP170), transcript variant alpha, mRNA. RefSeq Summary (NM_014812): The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:243,287,730-243,418,708 Size: 130,979 Total Exon Count: 20 Strand: - Coding Region Position: hg19 chr1:243,289,751-243,388,582 Size: 98,832 Coding Exon Count: 19
ID:CE170_HUMAN DESCRIPTION: RecName: Full=Centrosomal protein of 170 kDa; Short=Cep170; AltName: Full=KARP-1-binding protein; Short=KARP1-binding protein; FUNCTION: Plays a role in microtubule organization. SUBUNIT: Interacts with PLK1. INTERACTION: P12520:vpr (xeno); NbExp=4; IntAct=EBI-1104799, EBI-6164519; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Note=Associated with the mature mother centriole. Associated with spindle microtubules during mitosis. PTM: Phosphorylated; probably by PLK1. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the CEP170 family. SIMILARITY: Contains 1 FHA domain. SEQUENCE CAUTION: Sequence=BAA32315.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5SW79
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
