Human Gene DBX1 (uc021qez.1)
  Description: Homo sapiens developing brain homeobox 1 (DBX1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:20,177,761-20,181,870 Size: 4,110 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr11:20,177,763-20,181,867 Size: 4,105 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:20,177,761-20,181,870)mRNA (may differ from genome)Protein (381 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCLynxMalacardsMGIPubMed
TreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F8W811_HUMAN
DESCRIPTION: SubName: Full=Homeobox protein DBX1;
SUBCELLULAR LOCATION: Nucleus (By similarity).
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DBX1
CDC HuGE Published Literature: DBX1
Positive Disease Associations: Metabolism , Waist-Hip Ratio
Related Studies:
  1. Metabolism
    , , . [PubMed 0]
  2. Waist-Hip Ratio
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: DBX1
Diseases sorted by gene-association score: central hypoventilation syndrome, congenital (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.30 RPKM in Testis
Total median expression: 0.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on F8W811
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  LF213087 - JP 2014500723-A/20590: Polycomb-Associated Non-Coding RNAs.
MA448664 - JP 2018138019-A/20590: Polycomb-Associated Non-Coding RNAs.
LF207699 - JP 2014500723-A/15202: Polycomb-Associated Non-Coding RNAs.
BC172465 - Synthetic construct Homo sapiens clone IMAGE:100069159, MGC:199170 developing brain homeobox 1 (DBX1) mRNA, encodes complete protein.
BC156154 - Synthetic construct Homo sapiens clone IMAGE:100062464, MGC:190522 developing brain homeobox 1 (DBX1) mRNA, encodes complete protein.
LF212109 - JP 2014500723-A/19612: Polycomb-Associated Non-Coding RNAs.
MA443276 - JP 2018138019-A/15202: Polycomb-Associated Non-Coding RNAs.
MA447686 - JP 2018138019-A/19612: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC156154, F8W811, F8W811_HUMAN, NM_001029865, NP_001025036
UCSC ID: uc021qez.1
RefSeq Accession: NM_001029865
Protein: F8W811

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC156154.1
exon count: 4CDS single in 3' UTR: no RNA size: 1210
ORF size: 1143CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 2035.50frame shift in genome: no % Coverage: 94.79
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.