Description: Homo sapiens killer cell lectin-like receptor subfamily C, member 3 (KLRC3), transcript variant 2, mRNA. RefSeq Summary (NM_007333): Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr12:10,568,183-10,573,194 Size: 5,012 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr12:10,568,207-10,573,149 Size: 4,943 Coding Exon Count: 6
ID:J3KPJ5_HUMAN DESCRIPTION: SubName: Full=NKG2-E type II integral membrane protein; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on J3KPJ5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
L14542 - Human lectin-like type II integral membrane protein (NKG2-E) mRNA, complete cds. AF461157 - Homo sapiens NKG2E mRNA, complete cds. AF350016 - Homo sapiens NKG2E (NKG2E) mRNA, NKG2E02 allele, complete cds. AF350017 - Homo sapiens NKG2E (NKG2E) mRNA, NKG2E03 allele, complete cds. AF078550 - Homo sapiens lectin-like type II integral membrane protein (NKG2H) mRNA, alternatively spliced, complete cds. BC160065 - Synthetic construct Homo sapiens clone IMAGE:100064001, MGC:193180 killer cell lectin-like receptor subfamily C, member 3 (KLRC3) mRNA, encodes complete protein. AK307860 - Homo sapiens cDNA, FLJ97808. AK311162 - Homo sapiens cDNA, FLJ18204.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04612 - Antigen processing and presentation hsa04650 - Natural killer cell mediated cytotoxicity
BioCarta from NCI Cancer Genome Anatomy Project h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity
US Server
