Description: Homo sapiens cyclin B1 interacting protein 1, E3 ubiquitin protein ligase (CCNB1IP1), transcript variant 4, mRNA. RefSeq Summary (NM_182852): HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]. Transcript (Including UTRs) Position: hg19 chr14:20,779,527-20,801,471 Size: 21,945 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr14:20,779,709-20,784,682 Size: 4,974 Coding Exon Count: 3
ID:CIP1_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase CCNB1IP1; EC=6.3.2.-; AltName: Full=Cyclin-B1-interacting protein 1; AltName: Full=Human enhancer of invasion 10; FUNCTION: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Binds CCNB1 and UBE2L3. INTERACTION: P62972:- (xeno); NbExp=2; IntAct=EBI-745269, EBI-412964; P14635:CCNB1; NbExp=2; IntAct=EBI-745269, EBI-495332; SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=May associate with segregating chromosomes during metaphase and anaphase. TISSUE SPECIFICITY: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung. PTM: Ubiquitinated; autoubiquitinated. PTM: Phosphorylated by CDK1 on serine or threonine residues (in vitro). SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NPC3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.