Human Gene CCNB1IP1 (uc021rnp.2)
  Description: Homo sapiens cyclin B1 interacting protein 1, E3 ubiquitin protein ligase (CCNB1IP1), transcript variant 4, mRNA.
RefSeq Summary (NM_182852): HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004].
Transcript (Including UTRs)
   Position: hg19 chr14:20,779,527-20,801,471 Size: 21,945 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr14:20,779,709-20,784,682 Size: 4,974 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:20,779,527-20,801,471)mRNA (may differ from genome)Protein (277 aa)
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OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CIP1_HUMAN
DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase CCNB1IP1; EC=6.3.2.-; AltName: Full=Cyclin-B1-interacting protein 1; AltName: Full=Human enhancer of invasion 10;
FUNCTION: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
PATHWAY: Protein modification; protein ubiquitination.
SUBUNIT: Binds CCNB1 and UBE2L3.
INTERACTION: P62972:- (xeno); NbExp=2; IntAct=EBI-745269, EBI-412964; P14635:CCNB1; NbExp=2; IntAct=EBI-745269, EBI-495332;
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=May associate with segregating chromosomes during metaphase and anaphase.
TISSUE SPECIFICITY: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
PTM: Ubiquitinated; autoubiquitinated.
PTM: Phosphorylated by CDK1 on serine or threonine residues (in vitro).
SIMILARITY: Contains 1 RING-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CCNB1IP1
CDC HuGE Published Literature: CCNB1IP1
Positive Disease Associations: Alcohol Drinking
Related Studies:
  1. Alcohol Drinking
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.33 RPKM in Ovary
Total median expression: 535.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -210.00670-0.313 Picture PostScript Text
3' UTR -59.20182-0.325 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF14634 - zinc-RING finger domain

ModBase Predicted Comparative 3D Structure on Q9NPC3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity

Biological Process:
GO:0001825 blastocyst formation
GO:0007131 reciprocal meiotic recombination
GO:0007286 spermatid development
GO:0016567 protein ubiquitination
GO:0051026 chiasma assembly
GO:0051321 meiotic cell cycle

Cellular Component:
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0005634 nucleus
GO:0005694 chromosome


-  Descriptions from all associated GenBank mRNAs
  BC001218 - Homo sapiens cyclin B1 interacting protein 1, mRNA (cDNA clone MGC:839 IMAGE:3528496), complete cds.
AK026233 - Homo sapiens cDNA: FLJ22580 fis, clone HSI02563.
AK225451 - Homo sapiens mRNA for cyclin B1 interacting protein 1 isoform a variant, clone: HSI02563.
AK226037 - Homo sapiens mRNA for cyclin B1 interacting protein 1 isoform a variant, clone: FCC102F07.
AL161994 - Homo sapiens mRNA; cDNA DKFZp564A0772 (from clone DKFZp564A0772).
BC000369 - Homo sapiens cyclin B1 interacting protein 1, mRNA (cDNA clone MGC:8333 IMAGE:2819346), complete cds.
BC004435 - Homo sapiens cyclin B1 interacting protein 1, mRNA (cDNA clone MGC:3982 IMAGE:2819346), complete cds.
GQ900994 - Homo sapiens clone HEL-T-106 epididymis secretory sperm binding protein mRNA, complete cds.
AK225253 - Homo sapiens mRNA for cyclin B1 interacting protein 1 isoform a variant, clone: DMC01649.
BX247978 - human full-length cDNA clone CS0DF024YF10 of Fetal brain of Homo sapiens (human).
BX161424 - human full-length cDNA clone CS0DI003YE03 of Placenta of Homo sapiens (human).
BX161423 - human full-length cDNA clone CS0DI002YK24 of Placenta of Homo sapiens (human).
JD558785 - Sequence 539809 from Patent EP1572962.
JD430959 - Sequence 411983 from Patent EP1572962.
JD388441 - Sequence 369465 from Patent EP1572962.
JD429509 - Sequence 410533 from Patent EP1572962.
JD085885 - Sequence 66909 from Patent EP1572962.
AF216381 - Homo sapiens enhancer of invasion 10 (HEI10) mRNA, complete cds.
KJ894460 - Synthetic construct Homo sapiens clone ccsbBroadEn_03854 CCNB1IP1 gene, encodes complete protein.
AB528099 - Synthetic construct DNA, clone: pF1KE0444, Homo sapiens CCNB1IP1 gene for cyclin B1 interacting protein 1, without stop codon, in Flexi system.
AM393093 - Synthetic construct Homo sapiens clone IMAGE:100001949 for hypothetical protein (CCNB1IP1 gene).
AM393651 - Synthetic construct Homo sapiens clone IMAGE:100001956 for hypothetical protein (CCNB1IP1 gene).
AK309183 - Homo sapiens cDNA, FLJ99224.
JD225042 - Sequence 206066 from Patent EP1572962.
JD181569 - Sequence 162593 from Patent EP1572962.
JD422284 - Sequence 403308 from Patent EP1572962.
JD182354 - Sequence 163378 from Patent EP1572962.
JD054694 - Sequence 35718 from Patent EP1572962.
JD563929 - Sequence 544953 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C14orf18, CIP1_HUMAN, HEI10, NM_182852, NP_878272, Q9NPC3, uc021rnp.1
UCSC ID: uc021rnp.2
RefSeq Accession: NM_182852
Protein: Q9NPC3 (aka CIP1_HUMAN)
CCDS: CCDS9547.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_182852.3
exon count: 8CDS single in 3' UTR: no RNA size: 1686
ORF size: 834CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1588.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 1
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.