Human Gene TCL6 (uc021sbf.1)
  Description: Homo sapiens T-cell leukemia/lymphoma 6 (non-protein coding) (TCL6), non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr14:96,117,515-96,138,184 Size: 20,670 Total Exon Count: 8 Strand: +


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:96,117,515-96,138,184)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerHGNCLynxMalacardsPubMed

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TCL6
CDC HuGE Published Literature: TCL6
Positive Disease Associations: Heart Rate , QT interval
Related Studies:
  1. Heart Rate
    Fabio Marroni et al. Circulation. Cardiovascular genetics 2009, A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project., Circulation. Cardiovascular genetics. [PubMed 20031603]
    Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.
  2. QT interval
    Marroni ,et al. 2009, A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations: The EUROSPAN Project, Circulation. Cardiovascular genetics 2009 2- 4 : 322-8. [PubMed 20031603]
    Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.

-  MalaCards Disease Associations
  MalaCards Gene Search: TCL6
Diseases sorted by gene-association score: t-cell leukemia (21)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.68 RPKM in Spleen
Total median expression: 2.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BX161462 - human full-length cDNA clone CS0DI060YI15 of Placenta of Homo sapiens (human).
AB035338 - Homo sapiens TCL6e1 mRNA for T-cell leukemia/lymphoma 6 ORF163, complete cds, clone:pPLE1.
AB035337 - Homo sapiens TCL6d1 mRNA for T-cell leukemia/lymphoma 6 ORF119, complete cds, clone:pPLD1.
JD561752 - Sequence 542776 from Patent EP1572962.
JD407916 - Sequence 388940 from Patent EP1572962.
JD296146 - Sequence 277170 from Patent EP1572962.
JD313858 - Sequence 294882 from Patent EP1572962.
JD332513 - Sequence 313537 from Patent EP1572962.
JD199837 - Sequence 180861 from Patent EP1572962.
JD319931 - Sequence 300955 from Patent EP1572962.
JD342500 - Sequence 323524 from Patent EP1572962.
JD480599 - Sequence 461623 from Patent EP1572962.
JD480845 - Sequence 461869 from Patent EP1572962.
JD094004 - Sequence 75028 from Patent EP1572962.
JD136583 - Sequence 117607 from Patent EP1572962.
JD505994 - Sequence 487018 from Patent EP1572962.
JD309902 - Sequence 290926 from Patent EP1572962.
JD310933 - Sequence 291957 from Patent EP1572962.
JD500287 - Sequence 481311 from Patent EP1572962.
JD238623 - Sequence 219647 from Patent EP1572962.
JD080698 - Sequence 61722 from Patent EP1572962.
JD065429 - Sequence 46453 from Patent EP1572962.
JD509418 - Sequence 490442 from Patent EP1572962.
JD323294 - Sequence 304318 from Patent EP1572962.
JD204479 - Sequence 185503 from Patent EP1572962.
JD038159 - Sequence 19183 from Patent EP1572962.
JD519552 - Sequence 500576 from Patent EP1572962.
JD392305 - Sequence 373329 from Patent EP1572962.
JD153456 - Sequence 134480 from Patent EP1572962.
JD162355 - Sequence 143379 from Patent EP1572962.
JD282046 - Sequence 263070 from Patent EP1572962.
JD282047 - Sequence 263071 from Patent EP1572962.
JD282048 - Sequence 263072 from Patent EP1572962.
JD269924 - Sequence 250948 from Patent EP1572962.
JD234023 - Sequence 215047 from Patent EP1572962.
JD247139 - Sequence 228163 from Patent EP1572962.
JD060968 - Sequence 41992 from Patent EP1572962.
JD160540 - Sequence 141564 from Patent EP1572962.
JD255717 - Sequence 236741 from Patent EP1572962.
JD425854 - Sequence 406878 from Patent EP1572962.
JD212174 - Sequence 193198 from Patent EP1572962.
AB035332 - Homo sapiens TCL6a1 mRNA for T-cell leukemia/lymphoma 6 ORF141, complete cds.
AB035335 - Homo sapiens TCL6c1 mRNA for T-cell leukemia/lymphoma 6 ORF105, complete cds, clone:pPLC1.
AB035333 - Homo sapiens TCL6a2 mRNA for T-cell leukemia/lymphoma 6 ORF141, complete cds, clone:pPLA2.
AB035334 - Homo sapiens TCL6a3 mRNA for T-cell leukemia/lymphoma 6 ORF141, complete cds, clone:pPLA3.
AB035340 - Homo sapiens TCL6f1 mRNA for T-cell leukemia/lymphoma 6 ORF141, T-cell leukemia/lymphoma 6 ORF72, complete cds, clone:pDG1.
AB035341 - Homo sapiens TCL6f2 mRNA for T-cell leukemia/lymphoma 6 ORF141, T-cell leukemia/lymphoma 6 ORF72, complete cds, clone:pDG2.
AB035342 - Homo sapiens TCL6f3 mRNA for T-cell leukemia/lymphoma 6 ORF105, T-cell leukemia/lymphoma 6 ORF72, complete cds, clone:pDG3.
AB035343 - Homo sapiens TCL6f4 mRNA for T-cell leukemia/lymphoma 6 ORF105, T-cell leukemia/lymphoma 6 ORF72, complete cds, clone:pDG4.
JD309103 - Sequence 290127 from Patent EP1572962.
JD479346 - Sequence 460370 from Patent EP1572962.
JD324113 - Sequence 305137 from Patent EP1572962.
JD387004 - Sequence 368028 from Patent EP1572962.
AB527995 - Synthetic construct DNA, clone: pF1KB6823, Homo sapiens TCL6 gene for T-cell leukemia/lymphoma protein 6, without stop codon, in Flexi system.
JD275802 - Sequence 256826 from Patent EP1572962.
JD050505 - Sequence 31529 from Patent EP1572962.
JD127766 - Sequence 108790 from Patent EP1572962.
JD068408 - Sequence 49432 from Patent EP1572962.
JD104386 - Sequence 85410 from Patent EP1572962.
JD297276 - Sequence 278300 from Patent EP1572962.
JD167973 - Sequence 148997 from Patent EP1572962.
BC041075 - Homo sapiens T-cell leukemia/lymphoma 6, mRNA (cDNA clone MGC:52120 IMAGE:5923478), complete cds.
AF195821 - Homo sapiens Tng2 (TNG2) mRNA, complete cds.
JD083768 - Sequence 64792 from Patent EP1572962.
AB035339 - Homo sapiens TCL6g1 mRNA, 3'UTR, clone:pPLG1.
JD432176 - Sequence 413200 from Patent EP1572962.
JD498999 - Sequence 480023 from Patent EP1572962.
JD498998 - Sequence 480022 from Patent EP1572962.
JD167773 - Sequence 148797 from Patent EP1572962.
JD530247 - Sequence 511271 from Patent EP1572962.
JD230702 - Sequence 211726 from Patent EP1572962.
JD360139 - Sequence 341163 from Patent EP1572962.
JD302340 - Sequence 283364 from Patent EP1572962.
JD151121 - Sequence 132145 from Patent EP1572962.
JD231310 - Sequence 212334 from Patent EP1572962.
JD203153 - Sequence 184177 from Patent EP1572962.
JD168581 - Sequence 149605 from Patent EP1572962.
JD039279 - Sequence 20303 from Patent EP1572962.
JD049341 - Sequence 30365 from Patent EP1572962.
JD040876 - Sequence 21900 from Patent EP1572962.
JD319048 - Sequence 300072 from Patent EP1572962.
JD368749 - Sequence 349773 from Patent EP1572962.
JD368750 - Sequence 349774 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AB035338
UCSC ID: uc021sbf.1
RefSeq Accession: NR_028288

-  Gene Model Information
 
category: noncoding nonsense-mediated-decay: no RNA accession: AB035338.1
exon count: 8CDS single in 3' UTR: no RNA size: 2223
ORF size: 0CDS single in intron: no Alignment % ID: 99.63
txCdsPredict score: 283.00frame shift in genome: no % Coverage: 98.52
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 867# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.