Human Gene RRM2 (uc021vds.1)
  Description: Homo sapiens chromosome 2 open reading frame 48 (RRM2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:10,281,981-10,350,942 Size: 68,962 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr2:10,282,010-10,350,723 Size: 68,714 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:10,281,981-10,350,942)mRNA (may differ from genome)Protein (159 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RRM2
CDC HuGE Published Literature: RRM2

-  MalaCards Disease Associations
  MalaCards Gene Search: RRM2
Diseases sorted by gene-association score: choriocarcinoma (4), pancreas adenocarcinoma (3), pancreatic cancer (2), hepatocellular carcinoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.76 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 4.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.7029-0.266 Picture PostScript Text
3' UTR -86.50219-0.395 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q96LS8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK057831 - Homo sapiens cDNA FLJ25102 fis, clone CBR01369.
BC093999 - Homo sapiens chromosome 2 open reading frame 48, mRNA (cDNA clone MGC:121034 IMAGE:7939844), complete cds.
BC094001 - Homo sapiens chromosome 2 open reading frame 48, mRNA (cDNA clone MGC:121036 IMAGE:7939846), complete cds.
KJ896121 - Synthetic construct Homo sapiens clone ccsbBroadEn_05515 C2orf48 gene, encodes complete protein.
JD332568 - Sequence 313592 from Patent EP1572962.
JD354276 - Sequence 335300 from Patent EP1572962.
JD203094 - Sequence 184118 from Patent EP1572962.
JD139623 - Sequence 120647 from Patent EP1572962.
JD335131 - Sequence 316155 from Patent EP1572962.
JD220417 - Sequence 201441 from Patent EP1572962.
JD204038 - Sequence 185062 from Patent EP1572962.
JD460450 - Sequence 441474 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C2orf48, CB048_HUMAN, NM_182626, NP_872432, Q96LS8
UCSC ID: uc021vds.1
RefSeq Accession: NM_182626
Protein: Q96LS8 (aka CB048_HUMAN)
CCDS: CCDS1670.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_182626.2
exon count: 3CDS single in 3' UTR: no RNA size: 728
ORF size: 480CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1036.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.