Description: Homo sapiens syntaxin 16 (STX16), transcript variant 5, mRNA. RefSeq Summary (NM_001204868): This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]. Transcript (Including UTRs) Position: hg19 chr20:57,226,309-57,254,582 Size: 28,274 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr20:57,242,561-57,251,347 Size: 8,787 Coding Exon Count: 7
ID:STX16_HUMAN DESCRIPTION: RecName: Full=Syntaxin-16; Short=Syn16; FUNCTION: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. SUBUNIT: Interacts with GCC2. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type IV membrane protein. SUBCELLULAR LOCATION: Isoform C: Cytoplasm. TISSUE SPECIFICITY: Ubiquitous. DISEASE: Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B) [MIM:603233]. Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B. SIMILARITY: Belongs to the syntaxin family. SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain. SEQUENCE CAUTION: Sequence=AAB69282.1; Type=Frameshift; Positions=142, 163, 165; Sequence=AAB69283.1; Type=Frameshift; Positions=142, 163, 165; Sequence=AAC05647.1; Type=Frameshift; Positions=142, 163, 165;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14662
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB209296 - Homo sapiens mRNA for syntaxin 16 isoform a variant protein. AK316547 - Homo sapiens cDNA, FLJ79446 complete cds, highly similar to Syntaxin-16. AK304867 - Homo sapiens cDNA FLJ60226 complete cds, highly similar to Syntaxin-16. BC019042 - Homo sapiens syntaxin 16, mRNA (cDNA clone MGC:20765 IMAGE:4585425), complete cds. AF008935 - Homo sapiens syntaxin-16A mRNA, complete cds. AF008936 - Homo sapiens syntaxin-16B mRNA, complete cds. AF008937 - Homo sapiens syntaxin-16C mRNA, complete cds. BC073876 - Homo sapiens syntaxin 16, mRNA (cDNA clone MGC:90328 IMAGE:4371823), complete cds. AF428146 - Homo sapiens syntaxin-16D mRNA, complete cds. AF038897 - Homo sapiens syntaxin 16 mRNA, complete cds. AK026970 - Homo sapiens cDNA: FLJ23317 fis, clone HEP12062, highly similar to AF008936 Homo sapiens syntaxin-16B mRNA. AK296282 - Homo sapiens cDNA FLJ57384 complete cds, highly similar to Syntaxin-16. KM576712 - Homo sapiens clone STX16-NPEPL1_S8-N2a-N3out mRNA sequence. KM576713 - Homo sapiens clone STX16-NPEPL1_S8-N2b-N3out mRNA sequence. KM576714 - Homo sapiens clone STX16-NPEPL1_S8-intergenicexons1_2-N2b-N3out mRNA sequence. KM576711 - Homo sapiens clone STX16-NPEPL1_S8-intergenicexon2-N2a-N3out mRNA sequence. AK026974 - Homo sapiens cDNA: FLJ23321 fis, clone HEP12396. DQ268529 - Homo sapiens syntaxin 16 isoform C-like protein (STX16) mRNA, 3' UTR. AF305817 - Homo sapiens PRO0715 mRNA, complete cds. DQ272217 - Homo sapiens syntaxin 16 (STX16) mRNA, 3' UTR. JD340812 - Sequence 321836 from Patent EP1572962. JD348284 - Sequence 329308 from Patent EP1572962. JD556306 - Sequence 537330 from Patent EP1572962. JD556305 - Sequence 537329 from Patent EP1572962. JD522254 - Sequence 503278 from Patent EP1572962. JD522253 - Sequence 503277 from Patent EP1572962. JD104978 - Sequence 86002 from Patent EP1572962. JD317526 - Sequence 298550 from Patent EP1572962. JD069504 - Sequence 50528 from Patent EP1572962. JD540399 - Sequence 521423 from Patent EP1572962. JD199453 - Sequence 180477 from Patent EP1572962. JD179070 - Sequence 160094 from Patent EP1572962. DQ589075 - Homo sapiens piRNA piR-56187, complete sequence.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04130 - SNARE interactions in vesicular transport
Reactome (by CSHL, EBI, and GO)
Protein O14662 (Reactome details) participates in the following event(s):
R-HSA-6814678 ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN R-HSA-6814683 NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN R-HSA-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6814674 Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins R-HSA-6814676 SNAPs and NSF hexamer bind cis-SNARE at the TGN R-HSA-6814684 cis-SNARE binds SNAPs and NSF hexamer at the TGN R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811438 Intra-Golgi traffic R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport