Human Gene DGCR5 (uc021wku.1)
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Sequence and Links to Tools and Databases
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Primer design for this transcript
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Genetic Association Studies of Complex Diseases and Disorders
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Genetic Association Database (archive): DGCR5
CDC HuGE Published Literature: DGCR5
Positive Disease Associations: Blood Coagulation Factors
, Body Mass Index
, Cholesterol
, Cholesterol, HDL
, Cholesterol, LDL
, Metabolism
, Parkinson Disease
Related Studies: - Blood Coagulation Factors
Qiong Yang et al. BMC medical genetics 2007, Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903294]
Using genome-wide association methodology, we have successfully identified a SNP in complete LD with a sequence variant previously shown to be strongly associated with factor VII, providing proof of principle for this approach. Further study of additional strongly associated SNPs and linked regions may identify novel variants that influence the inter-individual variability in hemostatic factors and hematological phenotypes.
- Blood Coagulation Factors
Qiong Yang et al. BMC medical genetics 2007, Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903294]
Using genome-wide association methodology, we have successfully identified a SNP in complete LD with a sequence variant previously shown to be strongly associated with factor VII, providing proof of principle for this approach. Further study of additional strongly associated SNPs and linked regions may identify novel variants that influence the inter-individual variability in hemostatic factors and hematological phenotypes.
- Body Mass Index
Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
[PubMed 17903300]
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
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MalaCards Disease Associations
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Descriptions from all associated GenBank mRNAs
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X91348 - H.sapiens predicted non coding cDNA (DGCR5). AB051434 - Homo sapiens mRNA for KIAA1647 protein, partial cds. JD465930 - Sequence 446954 from Patent EP1572962. JD444852 - Sequence 425876 from Patent EP1572962. JD467118 - Sequence 448142 from Patent EP1572962. JD530010 - Sequence 511034 from Patent EP1572962. JD122967 - Sequence 103991 from Patent EP1572962. JD120401 - Sequence 101425 from Patent EP1572962.
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Other Names for This Gene
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Alternate Gene Symbols: NR_002733 UCSC ID: uc021wku.1 RefSeq Accession: NR_002733
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Gene Model Information
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category:
| noncoding
| nonsense-mediated-decay:
| no
| RNA accession:
| NR_002733.2
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exon count:
| 4 | CDS single in 3' UTR:
| no
| RNA size:
| 3334 |
ORF size:
| 0 | CDS single in intron:
| no
| Alignment % ID:
| 100.00 |
txCdsPredict score:
| 316.50 | frame shift in genome:
| no
| % Coverage:
| 99.67 |
has start codon:
| no
| stop codon in genome:
| no
| # of Alignments:
| 1 |
has end codon:
| no
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 2612 | # strange splices:
| 0 |
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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