Human Gene DCP1A (uc021wzk.1)
  Description: Homo sapiens decapping mRNA 1A (DCP1A), mRNA.
RefSeq Summary (NM_018403): Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014].
Transcript (Including UTRs)
   Position: hg19 chr3:53,324,826-53,381,654 Size: 56,829 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr3:53,324,827-53,381,544 Size: 56,718 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:53,324,826-53,381,654)mRNA (may differ from genome)Protein (443 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DCP1A
CDC HuGE Published Literature: DCP1A
Positive Disease Associations: Angiography , Blood Pressure
Related Studies:
  1. Angiography
    Ramachandran S Vasan et al. BMC medical genetics 2007, Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study., BMC medical genetics. [PubMed 17903301]
    In hypothesis-generating GWAS of echocardiography, ETT and BA vascular function in a moderate-sized community-based sample, we identified several SNPs that are candidates for replication attempts and we provide a web-based GWAS resource for the research community.
  2. Blood Pressure
    Daniel Levy et al. BMC medical genetics 2007, Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness., BMC medical genetics. [PubMed 17903302]
    These results of genome-wide association testing for blood pressure and arterial stiffness phenotypes in an unselected community-based sample of adults may aid in the identification of the genetic basis of hypertension and arterial disease, help identify high risk individuals, and guide novel therapies for hypertension. Additional studies are needed to replicate any associations identified in these analyses.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.60110-0.396 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010334 - DCP1

Pfam Domains:
PF06058 - Dcp1-like decapping family

SCOP Domains:
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on B4DHN9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF209983 - JP 2014500723-A/17486: Polycomb-Associated Non-Coding RNAs.
BC007439 - Homo sapiens DCP1 decapping enzyme homolog A (S. cerevisiae), mRNA (cDNA clone MGC:4252 IMAGE:3029175), complete cds.
AJ275986 - Homo sapiens mRNA for transcription factor (SMIF gene).
AB075507 - Homo sapiens neuroblastoma cDNA, clone:Nbla00360, full insert sequence.
AK295205 - Homo sapiens cDNA FLJ53884 complete cds, highly similar to mRNA decapping enzyme 1A (EC 3.-.-.-).
AK001969 - Homo sapiens cDNA FLJ11107 fis, clone PLACE1005803.
AY146651 - Homo sapiens decapping enzyme hDcp1a mRNA, complete cds.
KJ894264 - Synthetic construct Homo sapiens clone ccsbBroadEn_03658 DCP1A gene, encodes complete protein.
DQ893260 - Synthetic construct clone IMAGE:100005890; FLH195705.01X; RZPDo839F05152D DCP1 decapping enzyme homolog A (S. cerevisiae) (DCP1A) gene, encodes complete protein.
DQ896589 - Synthetic construct Homo sapiens clone IMAGE:100011049; FLH195701.01L; RZPDo839F05151D DCP1 decapping enzyme homolog A (S. cerevisiae) (DCP1A) gene, encodes complete protein.
AB590177 - Synthetic construct DNA, clone: pFN21AB9441, Homo sapiens DCP1A gene for DCP1 decapping enzyme homolog A, without stop codon, in Flexi system.
KU178716 - Homo sapiens DCP1 decapping enzyme-like protein A isoform 1 (DCP1A) mRNA, partial cds.
KU178717 - Homo sapiens DCP1 decapping enzyme-like protein A isoform 3 (DCP1A) mRNA, partial cds, alternatively spliced.
KU178718 - Homo sapiens DCP1 decapping enzyme-like protein A isoform 4 (DCP1A) mRNA, partial cds, alternatively spliced.
CU675659 - Synthetic construct Homo sapiens gateway clone IMAGE:100019905 5' read DCP1A mRNA.
MA445560 - JP 2018138019-A/17486: Polycomb-Associated Non-Coding RNAs.
LF333660 - JP 2014500723-A/141163: Polycomb-Associated Non-Coding RNAs.
LF333659 - JP 2014500723-A/141162: Polycomb-Associated Non-Coding RNAs.
LF333658 - JP 2014500723-A/141161: Polycomb-Associated Non-Coding RNAs.
LF333657 - JP 2014500723-A/141160: Polycomb-Associated Non-Coding RNAs.
LF333656 - JP 2014500723-A/141159: Polycomb-Associated Non-Coding RNAs.
LF333655 - JP 2014500723-A/141158: Polycomb-Associated Non-Coding RNAs.
MA569237 - JP 2018138019-A/141163: Polycomb-Associated Non-Coding RNAs.
MA569236 - JP 2018138019-A/141162: Polycomb-Associated Non-Coding RNAs.
MA569235 - JP 2018138019-A/141161: Polycomb-Associated Non-Coding RNAs.
MA569234 - JP 2018138019-A/141160: Polycomb-Associated Non-Coding RNAs.
MA569233 - JP 2018138019-A/141159: Polycomb-Associated Non-Coding RNAs.
MA569232 - JP 2018138019-A/141158: Polycomb-Associated Non-Coding RNAs.
LF333643 - JP 2014500723-A/141146: Polycomb-Associated Non-Coding RNAs.
JD226851 - Sequence 207875 from Patent EP1572962.
MA569220 - JP 2018138019-A/141146: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03018 - RNA degradation

-  Other Names for This Gene
  Alternate Gene Symbols: AK295205, B4DHN9, B4DHN9_HUMAN, NM_018403, NP_060873
UCSC ID: uc021wzk.1
RefSeq Accession: NM_018403
Protein: B4DHN9

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK295205.1
exon count: 7CDS single in 3' UTR: no RNA size: 1853
ORF size: 1329CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 2722.00frame shift in genome: no % Coverage: 72.21
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.