Description: Homo sapiens Zic family member 4 (ZIC4), transcript variant 2, mRNA. RefSeq Summary (NM_001168379): This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009]. Transcript (Including UTRs) Position: hg19 chr3:147,103,835-147,123,307 Size: 19,473 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr3:147,106,646-147,123,258 Size: 16,613 Coding Exon Count: 5
ID:J3KQG1_HUMAN DESCRIPTION: SubName: Full=Zinc finger protein ZIC 4; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on J3KQG1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK124600 - Homo sapiens cDNA FLJ42609 fis, clone BRACE3013119. AK127733 - Homo sapiens cDNA FLJ45833 fis, clone NT2RP8007715, weakly similar to Zinc finger protein ZIC4. JD429984 - Sequence 411008 from Patent EP1572962. AK126595 - Homo sapiens cDNA FLJ44632 fis, clone BRACE2019348, moderately similar to Zinc finger protein ZIC4. AK094286 - Homo sapiens cDNA FLJ36967 fis, clone BRACE2006089, highly similar to ZINC FINGER PROTEIN ZIC4. AK056394 - Homo sapiens cDNA FLJ31832 fis, clone NT2RP6000127, highly similar to Zinc finger protein ZIC 4. AK056262 - Homo sapiens cDNA FLJ31700 fis, clone NT2RI2006071, highly similar to Zinc finger protein ZIC 4. BC126267 - Homo sapiens Zic family member 4, mRNA (cDNA clone MGC:161545 IMAGE:8991983), complete cds. BC136339 - Homo sapiens Zic family member 4, mRNA (cDNA clone MGC:167949 IMAGE:9020326), complete cds. JD485280 - Sequence 466304 from Patent EP1572962. JD184919 - Sequence 165943 from Patent EP1572962. JD261743 - Sequence 242767 from Patent EP1572962. JD067451 - Sequence 48475 from Patent EP1572962. JD297116 - Sequence 278140 from Patent EP1572962. JD462404 - Sequence 443428 from Patent EP1572962. JD279822 - Sequence 260846 from Patent EP1572962. JD127366 - Sequence 108390 from Patent EP1572962. AK294831 - Homo sapiens cDNA FLJ58759 complete cds, highly similar to Zinc finger protein ZIC 4. AK293981 - Homo sapiens cDNA FLJ59672 complete cds, highly similar to Zinc finger protein ZIC 4. HQ258180 - Synthetic construct Homo sapiens clone IMAGE:100072489 Zic family member 4 (ZIC4), transcript variant 3 (ZIC4) gene, encodes complete protein. AF332509 - Homo sapiens zinc family member 4 protein HZIC4 (ZIC4) mRNA, complete cds. BC029507 - Homo sapiens Zic family member 4, mRNA (cDNA clone IMAGE:5288362), partial cds. JD406285 - Sequence 387309 from Patent EP1572962. JD187594 - Sequence 168618 from Patent EP1572962.