Description: Homo sapiens WD repeat domain 1 (WDR1), transcript variant 1, mRNA. RefSeq Summary (NM_017491): This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr4:10,075,963-10,118,573 Size: 42,611 Total Exon Count: 15 Strand: - Coding Region Position: hg19 chr4:10,077,002-10,118,290 Size: 41,289 Coding Exon Count: 15
Exercise Test Ramachandran S Vasan et al. BMC medical genetics 2007, Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903301]
In hypothesis-generating GWAS of echocardiography, ETT and BA vascular function in a moderate-sized community-based sample, we identified several SNPs that are candidates for replication attempts and we provide a web-based GWAS resource for the research community.
serum urate Wallace ,et al. 2008, Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia, American journal of human genetics 2008 82- 1 : 139-49.
[PubMed 18179892]
serum uric acid McArdle ,et al. 2008, Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish, Arthritis and rheumatism 2008 58- 9 : 2874-81.
[PubMed 18759275]
Our findings indicate that GLUT9, which is expressed in the kidney, may be a novel regulator of uric acid elimination and that a common nonsynonymous variant in this gene contributes to abnormalities in uric acid homeostasis and gout.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75083
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
