Human Gene C5orf63 (uc021ydc.1)
  Description: Homo sapiens chromosome 5 open reading frame 63 (C5orf63), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:126,386,996-126,409,184 Size: 22,189 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr5:126,387,463-126,394,687 Size: 7,225 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:126,386,996-126,409,184)mRNA (may differ from genome)Protein (115 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsH-INVHGNC
LynxMGIneXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: YD286_HUMAN
DESCRIPTION: RecName: Full=Glutaredoxin-like protein C5orf63;
SIMILARITY: Belongs to the glutaredoxin family. YDR286C subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.41 RPKM in Testis
Total median expression: 41.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.90151-0.251 Picture PostScript Text
3' UTR -121.76467-0.261 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008554 - Glutaredoxin-like
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF05768 - Glutaredoxin-like domain (DUF836)

SCOP Domains:
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on A6NC05
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsemblFlyBase SGD
 Protein SequenceProtein SequenceProtein Sequence Protein Sequence
 AlignmentAlignmentAlignment Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0055114 oxidation-reduction process


-  Descriptions from all associated GenBank mRNAs
  AK126569 - Homo sapiens cDNA FLJ44606 fis, clone BRACE2005991.
JD141283 - Sequence 122307 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NC05, NM_001164478, NP_001157950, YD286_HUMAN
UCSC ID: uc021ydc.1
RefSeq Accession: NM_001164478
Protein: A6NC05 (aka YD286_HUMAN)
CCDS: CCDS54896.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001164478.1
exon count: 5CDS single in 3' UTR: no RNA size: 966
ORF size: 348CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 896.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.