Human Gene DAXX (uc021zon.1)
  Description: Homo sapiens death-domain associated protein (DAXX), transcript variant 2, mRNA.
RefSeq Summary (NM_001350): This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].
Transcript (Including UTRs)
   Position: hg19 chr6_dbb_hap3:4,567,658-4,571,076 Size: 3,419 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr6_dbb_hap3:4,567,849-4,571,027 Size: 3,179 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6_dbb_hap3:4,567,658-4,571,076)mRNA (may differ from genome)Protein (682 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
HGNCLynxMalacardsMGIPubMedUniProtKB
Wikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DAXX
CDC HuGE Published Literature: DAXX
Positive Disease Associations: Cholesterol
Related Studies:
  1. Cholesterol
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: DAXX
Diseases sorted by gene-association score: gastric neuroendocrine tumor* (25), thalassemias, alpha- (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.1349-0.207 Picture PostScript Text
3' UTR -47.81191-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR005012 - Daxx

Pfam Domains:
PF03344 - Daxx N-terminal Rassf1C-interacting domain

ModBase Predicted Comparative 3D Structure on F5ANJ7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC000220 - Homo sapiens death-domain associated protein, mRNA (cDNA clone IMAGE:3353019), partial cds.
AK223404 - Homo sapiens mRNA for death-associated protein 6 variant, clone: FCC108C03.
AF015956 - Homo sapiens Fas-binding protein Daxx mRNA, complete cds.
AK303767 - Homo sapiens cDNA FLJ55943 complete cds, highly similar to Death domain-associated protein 6.
AB015051 - Homo sapiens mRNA for Daxx, complete cds.
AF097742 - Homo sapiens ETS1 associated protein EAP1/Daxx mRNA, complete cds.
AF050179 - Homo sapiens CENP-C binding protein (DAXX) mRNA, complete cds.
BC073776 - Homo sapiens cDNA clone IMAGE:2988484, containing frame-shift errors.
AF006041 - Homo sapiens Fas-binding protein (DAXX) mRNA, partial cds.
AB209493 - Homo sapiens mRNA for death-associated protein 6 variant protein.
AF039136 - Homo sapiens Fas binding protein (hDaxx) mRNA, complete cds.
AK292187 - Homo sapiens cDNA FLJ77778 complete cds, highly similar to Homo sapiens death-associated protein 6 (DAXX), mRNA.
JD170733 - Sequence 151757 from Patent EP1572962.
BC109073 - Homo sapiens death-domain associated protein, mRNA (cDNA clone MGC:126245 IMAGE:40034214), complete cds.
BC109074 - Homo sapiens death-domain associated protein, mRNA (cDNA clone MGC:126246 IMAGE:40034219), complete cds.
JD422618 - Sequence 403642 from Patent EP1572962.
JD286226 - Sequence 267250 from Patent EP1572962.
AK303854 - Homo sapiens cDNA FLJ50943 complete cds, highly similar to Death domain-associated protein 6.
JD271876 - Sequence 252900 from Patent EP1572962.
HQ436528 - Homo sapiens death domain-associated protein isoform beta (DAXX) mRNA, complete cds, alternatively spliced.
HQ436529 - Homo sapiens death domain-associated protein isoform gamma (DAXX) mRNA, complete cds, alternatively spliced.
CR457085 - Homo sapiens full open reading frame cDNA clone RZPDo834B036D for gene DAXX, death-associated protein 6; complete cds, incl. stopcodon.
AK313034 - Homo sapiens cDNA, FLJ93506, highly similar to Homo sapiens death-associated protein 6 (DAXX), mRNA.
KJ891029 - Synthetic construct Homo sapiens clone ccsbBroadEn_00423 DAXX gene, encodes complete protein.
EU446949 - Synthetic construct Homo sapiens clone IMAGE:100069977; IMAGE:100012158; FLH257100.01L death-associated protein 6 (DAXX) gene, encodes complete protein.
AB527719 - Synthetic construct DNA, clone: pF1KB6228, Homo sapiens DAXX gene for death-domain associated protein, without stop codon, in Flexi system.
AK309612 - Homo sapiens cDNA, FLJ99653.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa05014 - Amyotrophic lateral sclerosis (ALS)

BioCarta from NCI Cancer Genome Anatomy Project
h_fasPathway - FAS signaling pathway ( CD95 )
h_keratinocytePathway - Keratinocyte Differentiation
h_mapkPathway - MAPKinase Signaling Pathway
h_hsp27Pathway - Stress Induction of HSP Regulation
h_pmlPathway - Regulation of transcriptional activity by PML
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF
h_p38mapkPathway - p38 MAPK Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: F5ANJ7, F5ANJ7_HUMAN, HQ436529
UCSC ID: uc021zon.1
RefSeq Accession: NM_001350
Protein: F5ANJ7

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: HQ436529.1
exon count: 7CDS single in 3' UTR: no RNA size: 2053
ORF size: 2049CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 4215.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 5
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.