Description: Homo sapiens Ca++-dependent secretion activator 2 (CADPS2), transcript variant 1, mRNA. RefSeq Summary (NM_017954): This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]. Transcript (Including UTRs) Position: hg19 chr7:121,958,478-122,526,813 Size: 568,336 Total Exon Count: 30 Strand: - Coding Region Position: hg19 chr7:121,960,219-122,526,391 Size: 566,173 Coding Exon Count: 30
ID:CAPS2_HUMAN DESCRIPTION: RecName: Full=Calcium-dependent secretion activator 2; AltName: Full=Calcium-dependent activator protein for secretion 2; Short=CAPS-2; FUNCTION: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). SUBUNIT: Homodimer (By similarity). Interacts with the dopamine receptor DRD2. SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles. TISSUE SPECIFICITY: Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen. DOMAIN: The PH domain is essential for regulated exocytosis and binds phospholipids (By similarity). PTM: Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 MHD1 (MUNC13 homology domain 1) domain. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=AAH54339.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AK098170; Type=Miscellaneous discrepancy; Note=Chimera; Sequence=BAA91372.1; Type=Erroneous initiation; Sequence=BAB15210.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86UW7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
