Human Gene CDKN2B-AS1 (uc022beh.1)
  Description: Homo sapiens CDKN2B antisense RNA 1 (CDKN2B-AS1), transcript variant 7, non-coding RNA.
RefSeq Summary (NR_047537): This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014].
Transcript (Including UTRs)
   Position: hg19 chr9:21,994,790-22,121,093 Size: 126,304 Total Exon Count: 6 Strand: +


Page IndexSequence and LinksPrimersMalaCardsRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:21,994,790-22,121,093)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerHGNCLynxMalacardsPubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CDKN2B-AS1
Diseases sorted by gene-association score: intracranial aneurysm (35), periodontitis (23), endometriosis (11), aneurysm (8), open-angle glaucoma (6), glaucoma, normal tension (5), cerebral arterial disease (5), glaucoma 1, open angle, e (4)

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.30 RPKM in Colon - Transverse
Total median expression: 12.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  KT386339 - Homo sapiens cell-line MaMel-30 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, complete cds.
KT386340 - Homo sapiens cell-line MaMel-30 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, complete cds.
KT386341 - Homo sapiens cell-line MaMel-95 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, complete cds.
KT386352 - Homo sapiens cell-line MaMel122 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386351 - Homo sapiens cell-line MaMel100 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386348 - Homo sapiens cell-line UKRVMEL22b methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386344 - Homo sapiens cell-line MaMel13 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386345 - Homo sapiens cell-line MaMel61b methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386347 - Homo sapiens cell-line UKRVMEL32 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386342 - Homo sapiens cell-line UKRV-Mel22 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386349 - Homo sapiens cell-line MaMel66a methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386346 - Homo sapiens cell-line UKRVMEL20 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386343 - Homo sapiens cell-line MaMel24 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
KT386350 - Homo sapiens cell-line MaMel83 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence.
DQ485454 - Homo sapiens antisense noncoding RNA in the INK4 locus small transcript, complete sequence.
GQ422823 - Homo sapiens antisense noncoding RNA in the INK4 locus splice variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
GQ495926 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-9-10-12-13 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
GQ495925 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-15-16-17-18-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
AB548314 - Homo sapiens ANRIL ncRNA for antisense noncoding RNA in the INK4 locus transcript.
DQ485453 - Homo sapiens antisense noncoding RNA in the INK4 locus large transcript, complete sequence.
GQ495924 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-10-13 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
GQ495918 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
GQ495919 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
GQ495920 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-16-18-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
GQ495921 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
GQ495922 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-16-18-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
GQ495923 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-16-17-18-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced.
EU741058 - Homo sapiens antisense noncoding RNA in the INK4 locus splice variant (ANRIL), partial sequence, alternatively spliced.
MK574077 - Homo sapiens cell line HEK293T p14AS antisense RNA, complete sequence.
BC038540 - Homo sapiens, clone IMAGE:5187335, mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: NR_047537
UCSC ID: uc022beh.1
RefSeq Accession: NR_047537

-  Gene Model Information
 
category: noncoding nonsense-mediated-decay: no RNA accession: NR_047537.1
exon count: 6CDS single in 3' UTR: no RNA size: 1605
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: -54.50frame shift in genome: no % Coverage: 98.57
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.