Description: Homo sapiens CDKN2B antisense RNA 1 (CDKN2B-AS1), transcript variant 7, non-coding RNA. RefSeq Summary (NR_047537): This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]. Transcript (Including UTRs) Position: hg19 chr9:21,994,790-22,121,093 Size: 126,304 Total Exon Count: 6 Strand: +
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
KT386339 - Homo sapiens cell-line MaMel-30 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, complete cds. KT386340 - Homo sapiens cell-line MaMel-30 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, complete cds. KT386341 - Homo sapiens cell-line MaMel-95 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, complete cds. KT386352 - Homo sapiens cell-line MaMel122 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386351 - Homo sapiens cell-line MaMel100 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386348 - Homo sapiens cell-line UKRVMEL22b methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386344 - Homo sapiens cell-line MaMel13 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386345 - Homo sapiens cell-line MaMel61b methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386347 - Homo sapiens cell-line UKRVMEL32 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386342 - Homo sapiens cell-line UKRV-Mel22 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386349 - Homo sapiens cell-line MaMel66a methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386346 - Homo sapiens cell-line UKRVMEL20 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386343 - Homo sapiens cell-line MaMel24 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. KT386350 - Homo sapiens cell-line MaMel83 methylthioadenosine phosphorylase-/antisense noncoding RNA in INK4 fusion protein (MTAP-ANRIL fusion) mRNA, partial sequence. DQ485454 - Homo sapiens antisense noncoding RNA in the INK4 locus small transcript, complete sequence. GQ422823 - Homo sapiens antisense noncoding RNA in the INK4 locus splice variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. GQ495926 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-9-10-12-13 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. GQ495925 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-15-16-17-18-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. AB548314 - Homo sapiens ANRIL ncRNA for antisense noncoding RNA in the INK4 locus transcript. DQ485453 - Homo sapiens antisense noncoding RNA in the INK4 locus large transcript, complete sequence. GQ495924 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-10-13 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. GQ495918 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. GQ495919 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. GQ495920 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-16-18-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. GQ495921 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. GQ495922 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-16-18-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. GQ495923 - Homo sapiens antisense noncoding RNA in the INK4 locus 1-5-6-7-16-17-18-19-20 variant antisense RNA (CDKN2BAS), complete sequence, alternatively spliced. EU741058 - Homo sapiens antisense noncoding RNA in the INK4 locus splice variant (ANRIL), partial sequence, alternatively spliced. MK574077 - Homo sapiens cell line HEK293T p14AS antisense RNA, complete sequence. BC038540 - Homo sapiens, clone IMAGE:5187335, mRNA.